Department of Otolaryngology-Head and Neck Surgery. Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.
Head Neck. 2024 Apr;46(4):819-830. doi: 10.1002/hed.27631. Epub 2024 Jan 9.
There is growing evidence regarding the prognostic utility of ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIII) in head and neck squamous cell carcinoma (HNSCC). However, most studies to date include heterogeneous series with different treatments or tumor subsites.
We collected data from 201 patients with stage I-II glottic squamous cell carcinoma treated with transoral laser surgery. NLR, PLR, and SIII were calculated from preoperative cell blood count, cut-off points were obtained by ROC curve analysis, and survival rates were calculated.
High NLR (p = 0.012) and SIII (p = 0.037), but not PLR (p = 0.48), were associated with worse disease-specific survival (DSS). A similar trend was observed with overall survival (OS), although it did not reach statistical significance. On multivariable analyses, both high NLR (HR = 3.8, 95% CI = 1.5-9.9, p = 0.006) and high SIII (HR = 2.77, 95% CI = 1.1-6.9, p = 0.03) were significantly associated with shortened DSS.
Preoperative NLR and SIII emerge as independent prognostic biomarkers for early-stage surgically treated glottic tumors and could guide individualized follow-up.
越来越多的证据表明，中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和全身免疫炎症指数（SIII）等比值在头颈部鳞状细胞癌（HNSCC）中的预后具有一定作用。然而，迄今为止的大多数研究都包含了具有不同治疗方法或肿瘤亚部位的异质系列。
我们收集了 201 例接受经口激光手术治疗的 I 期- II 期声门型鳞状细胞癌患者的数据。从术前细胞血常规中计算 NLR、PLR 和 SIII，通过 ROC 曲线分析获得截断值，并计算生存率。
高 NLR（p=0.012）和 SIII（p=0.037），但不是 PLR（p=0.48）与疾病特异性生存率（DSS）较差相关。总体生存率（OS）也出现了类似的趋势，尽管没有达到统计学意义。在多变量分析中，高 NLR（HR=3.8，95%CI=1.5-9.9，p=0.006）和高 SIII（HR=2.77，95%CI=1.1-6.9，p=0.03）均与 DSS 缩短显著相关。
术前 NLR 和 SIII 是早期接受手术治疗的声门型肿瘤的独立预后生物标志物，可以指导个体化随访。
