Zhang Haofuzi, Jiang Xiaofan
Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Changle West Rd. 127, Xincheng District, Xi'an, Shaanxi, 710032, China.
Institute of Neurosurgery of People's Liberation Army of China (PLA), PLA's Key Laboratory of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Transl Neurosci. 2023 Dec 31;14(1):20220329. doi: 10.1515/tnsci-2022-0329. eCollection 2023 Jan 1.
David M. Holtzman and his team at the University of Washington School of Medicine have made breakthroughs in their research on neurodegenerative diseases. They discovered that the infiltration of T cells into the brain, instigated by activated microglia, is a critical factor in the progression of tauopathy. The groundbreaking findings were published in Nature on March 8, 2023. This research delineates a pivotal immune hub linked to tauopathy and neurodegeneration; a complex interplay involving activated microglia and T cell responses. This discovery could potentially become a target for developing therapeutic interventions for Alzheimer's disease and primary neurodegeneration.
华盛顿大学医学院的大卫·M·霍尔茨曼及其团队在神经退行性疾病研究方面取得了突破。他们发现，由活化的小胶质细胞引发的T细胞向大脑的浸润是tau蛋白病进展的关键因素。这一开创性的发现于2023年3月8日发表在《自然》杂志上。这项研究描绘了一个与tau蛋白病和神经退行性变相关的关键免疫枢纽；这是一个涉及活化小胶质细胞和T细胞反应的复杂相互作用。这一发现有可能成为开发阿尔茨海默病和原发性神经退行性变治疗干预措施的靶点。
