Ross E D, Stewart R S
J Nerv Ment Dis. 1987 Mar;175(3):165-72. doi: 10.1097/00005053-198703000-00007.
Two patients are reported with the acute onset of pathological crying following right inferior frontal brain damage. Both had severe endogenous depression and neither had pseudobulbar palsy. These and other cases argue that two organic brain diseases--one structural and the other "physiopharmacological"--may interact to produce pathological display of affect that cannot be accounted for by traditional neurological explanations. A pharmacological mechanism for the rapid amelioration of pathological affect by tricyclic medications and its possible relationship to the newly discovered descending motor systems of the brain that use norepinephrine and serotonin as neurotransmitters is offered. These cases also suggest that pathological affect is a valuable clinical indicator of an underlying major depression in some brain-injured patients.
本文报告了两例右侧额叶下部脑损伤后急性出现病理性哭泣的患者。两人均患有严重的内源性抑郁症，且均无假性延髓麻痹。这些病例以及其他病例表明，两种器质性脑疾病——一种是结构性的，另一种是“生理药理学性的”——可能相互作用，产生无法用传统神经学解释的情感病理性表现。本文提出了三环类药物快速改善病理性情感的药理学机制及其与新发现的以去甲肾上腺素和5-羟色胺作为神经递质的大脑下行运动系统的可能关系。这些病例还表明，病理性情感是一些脑损伤患者潜在重度抑郁症的重要临床指标。
