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抗结核药物致严重食管炎 1 例报告。

Severe esophagitis induced by antituberculosis drugs: a case report.

机构信息

Hospital Municipal Ronaldo Gazolla, Rio de Janeiro, Rio de Janeiro, Brazil.

Universidade Federal Fluminense, Faculdade de Medicina, Niterói, Rio de Janeiro, Brazil.

出版信息

Rev Inst Med Trop Sao Paulo. 2024 Jan 5;66:e2. doi: 10.1590/S1678-9946202466002. eCollection 2024.

DOI:10.1590/S1678-9946202466002
PMID:38198375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10768651/
Abstract

Tuberculosis stands as one of humanity's oldest afflictions, intrinsically intertwined with social disparities. This formidable disease spares no age group and remains the prevailing cause of infection-induced mortality worldwide, particularly in developing nations. We present a case of a 56-year-old woman with diabetes who was diagnosed with Pulmonary Tuberculosis. After receiving antituberculosis drugs as part of her treatment, she experienced a range of systemic manifestations and suffered from severe ulcerative esophagitis. This adverse reaction led to uncontrollable gastrointestinal intolerance, tragically resulting in her untimely demise. The incident underscores the potential seriousness of adverse reactions that can arise from tuberculosis treatment medications.

摘要

结核病是人类最古老的疾病之一,与社会不平等现象有着内在的联系。这种可怕的疾病没有年龄限制,仍然是全球感染性死亡的主要原因,尤其是在发展中国家。我们呈现了一例 56 岁糖尿病女性患者,她被诊断患有肺结核。在接受抗结核药物治疗后,她出现了一系列全身症状,并患有严重的溃疡性食管炎。这种不良反应导致无法控制的胃肠道不耐受,不幸导致她过早死亡。这一事件突显了结核病治疗药物可能引起的不良反应的潜在严重性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af34/10768651/e5b640a2fbe3/1678-9946-rimtsp-66-S1678-9946202466002-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af34/10768651/d1407ad5f977/1678-9946-rimtsp-66-S1678-9946202466002-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af34/10768651/e5b640a2fbe3/1678-9946-rimtsp-66-S1678-9946202466002-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af34/10768651/d1407ad5f977/1678-9946-rimtsp-66-S1678-9946202466002-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af34/10768651/e5b640a2fbe3/1678-9946-rimtsp-66-S1678-9946202466002-gf02.jpg

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本文引用的文献

1
Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021.2021 年胃食管反流病循证临床实践指南。
J Gastroenterol. 2022 Apr;57(4):267-285. doi: 10.1007/s00535-022-01861-z. Epub 2022 Feb 28.
2
Oesophageal Tuberculosis: A Systematic Review Focusing on Clinical Management.食管结核:聚焦临床管理的系统综述。
Dysphagia. 2022 Aug;37(4):973-987. doi: 10.1007/s00455-021-10360-x. Epub 2021 Sep 4.
3
Clinical Pharmacokinetics and Pharmacodynamics of Rifampicin in Human Tuberculosis.利福平在人类结核病中的临床药代动力学和药效学。
Clin Pharmacokinet. 2019 Sep;58(9):1103-1129. doi: 10.1007/s40262-019-00764-2.
4
Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs.结核病的风险因素:糖尿病、吸烟、饮酒以及使用其他药物。
J Bras Pneumol. 2018 Apr;44(2):145-152. doi: 10.1590/s1806-37562017000000443.
5
Risk factors associated with adverse reactions to antituberculosis drugs.与抗结核药物不良反应相关的危险因素。
J Bras Pneumol. 2015 Jan-Feb;41(1):77-89. doi: 10.1590/S1806-37132015000100010.
6
Clinical management of concurrent diabetes and tuberculosis and the implications for patient services.糖尿病与结核病并发的临床处理及对患者服务的影响。
Lancet Diabetes Endocrinol. 2014 Sep;2(9):740-53. doi: 10.1016/S2213-8587(14)70110-X.
7
Rifampin-associated pseudomembranous colitis.利福平相关的伪膜性结肠炎。
Am J Med Sci. 2009 Aug;338(2):156-8. doi: 10.1097/MAJ.0b013e31819f1eec.
8
Adverse reactions to first-line antituberculosis drugs.一线抗结核药物的不良反应。
Expert Opin Drug Saf. 2006 Mar;5(2):231-49. doi: 10.1517/14740338.5.2.231.
9
The endoscopic assessment of esophagitis: a progress report on observer agreement.食管炎的内镜评估:观察者一致性的进展报告
Gastroenterology. 1996 Jul;111(1):85-92. doi: 10.1053/gast.1996.v111.pm8698230.
10
Eosinophilic colitis due to rifampicin.利福平所致嗜酸性粒细胞性结肠炎
Lancet. 1994 Nov 5;344(8932):1296-7. doi: 10.1016/s0140-6736(94)90782-x.