Cheung Leong-Hung, To Jeffrey C, Wong Wai-Ki, Stuart Marc C A, Kajitani Takashi, Keng Vincent W, Leung Franco King-Chi
State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong 999077, China.
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747AG Groningen, Netherlands.
ACS Appl Mater Interfaces. 2024 Jan 24;16(3):4056-4070. doi: 10.1021/acsami.3c16795. Epub 2024 Jan 10.
Biocompatible synthetic supramolecular systems have shed light on biomedical and tissue-regenerative material applications. The intrinsic functional applicability, tunability, and stimuli-responsiveness of synthetic supramolecular systems allow one to develop various multicontrolled supramolecular assemblies in aqueous media. However, it remains highly challenging to use state-of-the-art supramolecular assemblies of photoresponsive amphiphiles controlled by multiple stimulations in fabricating macroscopic materials. Herein, we demonstrate a stiff-stilbene amphiphile (SA) multicontrolled supramolecular assembling system that comprises two different charged end groups. The excellent photoswitchabilities of SA in both organic and aqueous media are demonstrated. Furthermore, multiple stimuli, .., light, pH, and counterions, are applied to control the supramolecular assembling behaviors, which are monitored by circular dichroism spectroscopy and electron microscopies. This multicontrolled supramolecular system can be systematically assembled into macroscopic soft functional scaffolds, whose structural parameters are investigated by electron microscopies and X-ray diffraction techniques, suggesting the large aspect ratio of SA nanostructures assembled into macroscopic soft scaffolds. The fabricated soft functional scaffold is highly biocompatible for photocontrolled biotarget encapsulation/release selectively, as well as a cell-material interface for diverse cells' attachment. This new synthetic multicontrolled soft functional material provides a new strategy toward the development of next-generation controllable and biocompatible soft functional materials.
生物相容性合成超分子体系为生物医学和组织再生材料应用带来了曙光。合成超分子体系固有的功能适用性、可调节性和刺激响应性使得人们能够在水性介质中开发各种多控超分子组装体。然而，在制造宏观材料时，使用受多种刺激控制的光响应两亲分子的先进超分子组装体仍然极具挑战性。在此，我们展示了一种包含两个不同带电端基的刚性二苯乙烯两亲分子（SA）多控超分子组装体系。证明了SA在有机和水性介质中均具有出色的光开关性能。此外，施加多种刺激，如光、pH值和抗衡离子，以控制超分子组装行为，通过圆二色光谱和电子显微镜对其进行监测。这种多控超分子体系可以系统地组装成宏观软功能支架，通过电子显微镜和X射线衍射技术对其结构参数进行研究，表明组装成宏观软支架的SA纳米结构具有较大的纵横比。所制备的软功能支架具有高度生物相容性，可用于光控生物靶标的选择性封装/释放，以及作为多种细胞附着的细胞-材料界面。这种新型合成多控软功能材料为开发下一代可控且生物相容的软功能材料提供了新策略。
