痕量金属与星形胶质细胞的生理学和病理生理学。

Trace metals and astrocytes physiology and pathophysiology.

机构信息

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China; Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China; China Medical University Centre of Forensic Investigation, China.

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Achucarro Center for Neuroscience, Ikerbasque, Bilbao 48011, Spain; Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Vilnius LT-01102, Lithuania.

出版信息

Cell Calcium. 2024 Mar;118:102843. doi: 10.1016/j.ceca.2024.102843. Epub 2024 Jan 4.

DOI:10.1016/j.ceca.2024.102843

PMID:38199057

Abstract

Several trace metals, including iron, copper, manganese and zinc are essential for normal function of the nervous system. Both deficiency and excessive accumulation of these metals trigger neuropathological developments. The central nervous system (CNS) is in possession of dedicated homeostatic system that removes, accumulates, stores and releases these metals to fulfil nervous tissue demand. This system is mainly associated with astrocytes that act as dynamic reservoirs for trace metals, these being a part of a global system of CNS ionostasis. Here we overview physiological and pathophysiological aspects of astrocyte-cantered trace metals regulation.

摘要

几种痕量金属，包括铁、铜、锰和锌，对神经系统的正常功能至关重要。这些金属的缺乏和过量积累都会引发神经病理学的发展。中枢神经系统（CNS）拥有专门的体内平衡系统，用于清除、积累、储存和释放这些金属，以满足神经组织的需求。这个系统主要与星形胶质细胞有关，星形胶质细胞是痕量金属的动态储库，是中枢神经系统离子稳定的全球系统的一部分。在这里，我们综述了星形胶质细胞为中心的痕量金属调节的生理和病理生理方面。