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牡蛎肽锌复合物改善邻苯二甲酸二（2-乙基己基）酯诱导的雄性小鼠睾丸损伤并改善肠道微生物群。

Oyster Peptide-Zinc Complex Ameliorates Di-(2-ethylhexyl) Phthalate-Induced Testis Injury in Male Mice and Improving Gut Microbiota.

作者信息

Lu Zhen, Huang Qianqian, Chen Fujia, Li Enzhong, Lin Haisheng, Qin Xiaoming

机构信息

Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Science and Technology Innovation Center for Subtropical Fruit and Vegetable Processing, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.

School of Biological and Food Processing Engineering, Huanghuai University, Zhumadian 463000, China.

出版信息

Foods. 2023 Dec 27;13(1):93. doi: 10.3390/foods13010093.

DOI:10.3390/foods13010093
PMID:38201121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10778688/
Abstract

Di-(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer, which can cause damage to male reproductive organs, especially the atrophy of the testis. Meanwhile, DEHP can also lead to a decrease in testicular zinc content, but the role of zinc remains unclear. This study aims to prepare oyster peptide-zinc complex (OPZC) to alleviate DEHP-induced reproductive damage in mice. OPZC was successfully obtained through electron microscopy, X-ray diffraction, and thermogravimetric analysis, with stable structure and high water-solubility. Low dose oyster peptide-zinc complex (OPZCL) significantly reduced the reproductive damage caused by DEHP in mice. Further research had shown that OPZCL restored the content of serum hormones and the activity of oxidative stress kinases to normal, while also normalizing testicular zinc and selenium levels. In addition, it also recovered the disorder of gut microbiota, reduced the proportion of , increased the abundance of , and restored the proportion of , and . Therefore, OPZCL can relieve the reproductive damage caused by DEHP in mice by restoring testicular zinc homeostasis and the composition of intestinal microbiota, indicating that OPZCL has a potential protective effect on male reproductive health.

摘要

邻苯二甲酸二（2-乙基己基）酯（DEHP）是一种广泛使用的增塑剂，可对雄性生殖器官造成损害，尤其是睾丸萎缩。同时，DEHP还可导致睾丸锌含量降低，但锌的作用尚不清楚。本研究旨在制备牡蛎肽锌复合物（OPZC）以减轻DEHP诱导的小鼠生殖损伤。通过电子显微镜、X射线衍射和热重分析成功获得了OPZC，其结构稳定且水溶性高。低剂量牡蛎肽锌复合物（OPZCL）显著降低了DEHP对小鼠造成的生殖损伤。进一步研究表明，OPZCL可使血清激素含量和氧化应激激酶活性恢复正常，同时使睾丸锌和硒水平正常化。此外，它还恢复了肠道微生物群的紊乱，降低了 的比例，增加了 的丰度，并恢复了 和 的比例。因此，OPZCL可通过恢复睾丸锌稳态和肠道微生物群组成来减轻DEHP对小鼠造成的生殖损伤，表明OPZCL对男性生殖健康具有潜在的保护作用。

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