Li Dan, Lin Qinlu, Luo Feijun, Wang Hanqing
Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Processed Food for Special Medical Purpose, National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Hunan Engineering Research Center of Full Life-Cycle Energy-Efficient Buildings and Environmental Health, School of Civil Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Foods. 2023 Dec 31;13(1):145. doi: 10.3390/foods13010145.
Sialic acid (SA) is a kind of functional monosaccharide which exists widely in edible bird's nest (EBN), milk, meat, mucous membrane surface, etc. SA is an important functional component in promoting brain development, anti-oxidation, anti-inflammation, anti-virus, anti-tumor and immune regulation. The intestinal mucosa covers the microbial community that has a significant impact on health. In the gut, SA can also regulate gut microbiota and metabolites, participating in different biological functions. The structure, source and physiological functions of SA were reviewed in this paper. The biological functions of SA through regulating key signaling pathways and target genes were discussed. In summary, SA can modulate gut microbiota and metabolites, which affect gene expressions and exert its biological activities. It is helpful to provide scientific reference for the further investigation of SA in the functional foods.
唾液酸（SA）是一种功能性单糖，广泛存在于燕窝（EBN）、牛奶、肉类、粘膜表面等中。SA是促进大脑发育、抗氧化、抗炎、抗病毒、抗肿瘤和免疫调节的重要功能成分。肠粘膜覆盖着对健康有重大影响的微生物群落。在肠道中，SA还可以调节肠道微生物群和代谢产物，参与不同的生物学功能。本文综述了SA的结构、来源和生理功能。讨论了SA通过调节关键信号通路和靶基因发挥的生物学功能。总之，SA可以调节肠道微生物群和代谢产物，影响基因表达并发挥其生物学活性。这有助于为进一步研究SA在功能性食品中的应用提供科学参考。
