Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark.
Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark.
Cells. 2023 Dec 20;13(1):15. doi: 10.3390/cells13010015.
The heterogeneity of autoantibody targets in autoimmune encephalitides presents a challenge for understanding cellular and humoral pathophysiology, and the development of new treatment strategies. Thus, current treatment aims at autoantibody removal and immunosuppression, and is primarily based on data generated from other autoimmune neurological diseases and expert consensus. There are many subtypes of autoimmune encephalitides, which now entails both diseases with autoantibodies targeting extracellular antigens and classical paraneoplastic syndromes with autoantibodies targeting intracellular antigens. Here, we review the current knowledge of molecular and cellular effects of autoantibodies associated with autoimmune encephalitis, and evaluate the evidence behind the proposed pathophysiological mechanisms of autoantibodies in autoimmune encephalitis.
自身免疫性脑炎中自身抗体靶标的异质性给理解细胞和体液病理生理学以及新治疗策略的发展带来了挑战。因此，目前的治疗方法旨在清除自身抗体和免疫抑制，并且主要基于来自其他自身免疫性神经疾病和专家共识的数据。自身免疫性脑炎有许多亚型，现在既有针对细胞外抗原的自身抗体的疾病，也有针对细胞内抗原的经典副肿瘤综合征。在这里，我们回顾了与自身免疫性脑炎相关的自身抗体的分子和细胞作用的现有知识，并评估了自身免疫性脑炎中自身抗体提出的病理生理学机制的证据。
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