Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 15771 Athens, Greece.
Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, Poland.
Cells. 2023 Dec 29;13(1):70. doi: 10.3390/cells13010070.
Gentiopicroside (GPS) is a leading component of several plant species from the Gentianaceae botanical family. As a compound with plenty of biological activities and a component of herbal drugs, GPS has an important role in the regulation of physiological processes in humans. The results of recently published scientific studies underline a meaningful role of this molecule as an active factor in metabolic pathways and mechanisms, which may have an influence in the treatment of different diseases, including digestive tract disorders, malignant changes, neurological disorders, microbial infections, bone formation disorders, inflammatory conditions, and others. This review aims to collect previously published reports on the biological properties of GPS as a single compound that were confirmed by and studies, and to draw attention to the newly discovered role of this bitter-tasting secoiridoid. Thanks to these properties, the research on this substance could be revisited.
龙胆苦苷（GPS）是龙胆科植物的主要成分之一。作为一种具有多种生物活性的化合物和草药的组成部分，GPS 在调节人体生理过程中起着重要作用。最近发表的科学研究结果强调了该分子作为代谢途径和机制中活性因子的重要作用，这可能对治疗包括消化道疾病、恶性变化、神经紊乱、微生物感染、骨形成紊乱、炎症等在内的多种疾病有影响。本综述旨在收集以前发表的关于 GPS 作为单一化合物的生物学特性的报告，这些特性已被 和 研究证实，并提请注意这种苦的裂环环烯醚萜的新发现作用。由于这些特性，人们可以重新研究这种物质。
