高危个体胰腺癌监测的心理社会影响评估
Assessment of the Psychosocial Impact of Pancreatic Cancer Surveillance in High-Risk Individuals.
作者信息
Anez-Bruzual Isabel, Coughlin Sarah, Clay Daniel, Heiman Jordan, Dungan Michaela, Weber Marina, Almario Christopher V, Leung Galen, Ahmad Nuzhat A, Ginsberg Gregory G, Kochman Michael L, Valverde Kathleen D, Long Jessica M, Katona Bryson W
机构信息
Master of Science in Genetic Counseling Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Cancers (Basel). 2023 Dec 23;16(1):86. doi: 10.3390/cancers16010086.
OBJECTIVES
Pancreatic cancer (PC) surveillance of high-risk individuals (HRIs) downstages PC and improves survival. However, it remains less clear whether PC surveillance has a positive psychosocial impact on HRIs. Herein, we aimed to define the attitudes and beliefs of HRIs undergoing PC surveillance, and the immediate and sustained psychosocial impact of PC surveillance in HRIs.
METHODS
100 HRIs undergoing PC surveillance by endoscopic ultrasound (EUS) completed three surveys addressing different components of the psychosocial impact of PC surveillance. Logistic regression analyses were performed to identify predictive factors relating to these components.
RESULTS
Most HRIs reported increased perceived benefits of PC surveillance, self-efficacy, and perceived severity of PC. HRIs reported few negative emotions prior to surveillance and frequent positive emotions after surveillance. Compared to prior to surveillance, there was a 53.5% decrease in the level of distress reported by HRIs after surveillance, which was sustained for 4-6 weeks post-surveillance. Family history of PC and lower self-reported mental health were identified as predictors for increased perceived susceptibility to PC ( < 0.01) and greater change in distress pre- to post-surveillance ( < 0.01), respectively.
CONCLUSIONS
Our findings suggest that PC surveillance can lead to sustained psychosocial benefits in HRIs.
目的
对高危个体（HRIs）进行胰腺癌（PC）监测可使胰腺癌降期并提高生存率。然而，PC监测对HRIs是否具有积极的社会心理影响仍不太明确。在此，我们旨在明确接受PC监测的HRIs的态度和信念，以及PC监测对HRIs的即时和持续社会心理影响。
方法
100名通过内镜超声（EUS）接受PC监测的HRIs完成了三项调查，涉及PC监测社会心理影响的不同方面。进行逻辑回归分析以确定与这些方面相关的预测因素。
结果
大多数HRIs报告称，PC监测的感知益处、自我效能感以及对PC严重程度的感知均有所增加。HRIs报告在监测前负面情绪较少，监测后积极情绪频繁。与监测前相比，HRIs在监测后报告的痛苦程度降低了53.5%，且在监测后4至6周内持续存在。PC家族史和较低的自我报告心理健康水平分别被确定为PC易感性增加（<0.01）和监测前后痛苦变化更大（<0.01）的预测因素。
结论
我们的研究结果表明，PC监测可为HRIs带来持续的社会心理益处。
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