2006 - 2015年芬兰老年结直肠癌患者的短期和长期生存情况：一项基于全国人口登记的研究
Short- and Long-Term Survival among Elderly Colorectal Cancer Patients in Finland, 2006-2015: A Nationwide Population-Based Registry Study.
作者信息
Hukkinen Tanja, Olenius Tobias, Koskensalo Selja, Lepistö Anna, Koskenvuo Laura, Böckelman Camilla
机构信息
Department of Gastroenterological Surgery, Abdominal Center, Helsinki University Hospital, Faculty of Medicine, University of Helsinki, Meilahden Sairaalakampus, Palvelukeskus PAKE.PA3.30, Stenbäckinkatu 9A, PL 440, 00029 Helsinki, Finland.
出版信息
Cancers (Basel). 2023 Dec 27;16(1):135. doi: 10.3390/cancers16010135.
This population-based registry study aimed to report 30-day and one-year postoperative survival, five-year overall survival (OS), and disease-specific survival (DSS) among elderly (≥75 years old) colorectal cancer (CRC) patients. All new colorectal cancer cases from 2006-2015 were included and followed until death or the end of follow-up (end of 2016). Among 27,088 CRC patients, 11,306 patients were ≥75 years old. Among patients ≥ 75 years, 36.8% ( = 4160) had right-sided colon cancer, 21.9% ( = 2478) left-sided colon cancer, and 32.3% ( = 3650) rectal cancer. In this study population, 932 patients were aged ≥ 90. The 30-day postoperative OS for patients aged 75-79 was 96.1% (95% confidence interval [CI] 95.3-96.9) falling to 93.2% (95% CI 92.0-94.4) for patients aged 80-84. The one-year postoperative OS among patients aged 75-79 was 86.3% (95% CI 84.7-87.9) compared with 80.5% (95% CI 78.7-82.3) among patients aged 80-84. Five-year OS among patients aged 75-79 was 47.6% (95% CI 46.0-49.2) and 36.6% (95% CI 34.8-38.4) among patients aged 80-84, compared with 61.7% (95% CI 60.9-62.5) among younger patients (<75 years old). Survival among elderly CRC patients (≥75 years old) was in general fairly good when compared with younger patients, especially among patients aged 75-79 and 80-84 with localized or locally advanced disease.
这项基于人群的登记研究旨在报告老年（≥75岁）结直肠癌（CRC）患者术后30天和1年生存率、5年总生存率（OS）和疾病特异性生存率（DSS）。纳入了2006年至2015年所有新诊断的结直肠癌病例，并随访至死亡或随访结束（2016年底）。在27,088例CRC患者中，11,306例患者年龄≥75岁。在≥75岁的患者中，36.8%（=4160）患有右半结肠癌，21.9%（=2478）患有左半结肠癌，32.3%（=3650）患有直肠癌。在该研究人群中，932例患者年龄≥90岁。75至79岁患者术后30天OS为96.1%（95%置信区间[CI]95.3 - 96.9），80至84岁患者降至93.2%（95%CI 92.0 - 94.4）。75至79岁患者术后1年OS为86.3%（�5%CI 84.7 - 87.9），而80至84岁患者为80.5%（95%CI 78.7 - 82.3）。75至79岁患者5年OS为47.6%（95%CI 46.0 - 49.2），80至84岁患者为36.6%（95%CI 34.8 - 38.4），相比之下，年轻患者（<75岁）为61.7%（95%CI 60.9 - 62.5）。与年轻患者相比，老年CRC患者（≥75岁）的生存率总体相当不错，尤其是75至79岁和80至84岁患有局限性或局部晚期疾病的患者。
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