Yan Bohua, Hua Yabing, Wang Jinyue, Shao Tianjiao, Wang Shan, Gao Xiang, Gao Jing
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Department of Pharmacy, Xuzhou Medical University Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Polymers (Basel). 2024 Jan 4;16(1):165. doi: 10.3390/polym16010165.
Poly(lactic-glycolic acid) (PLGA) is a biocompatible bio-scaffold material, but its own hydrophobic and electrically neutral surface limits its application as a cell scaffold. Polymer materials, mimics ECM materials, and organic material have often been used as coating materials for PLGA cell scaffolds to improve the poor cell adhesion of PLGA and enhance tissue adaptation. These coating materials can be modified on the PLGA surface via simple physical or chemical methods, and coating multiple materials can simultaneously confer different functions to the PLGA scaffold; not only does this ensure stronger cell adhesion but it also modulates cell behavior and function. This approach to coating could facilitate the production of more PLGA-based cell scaffolds. This review focuses on the PLGA surface-modified materials, methods, and applications, and will provide guidance for PLGA surface modification.
聚乳酸-乙醇酸共聚物（PLGA）是一种生物相容性生物支架材料，但其自身的疏水和电中性表面限制了其作为细胞支架的应用。聚合物材料、模拟细胞外基质（ECM）的材料以及有机材料常被用作PLGA细胞支架的涂层材料，以改善PLGA较差的细胞黏附性并增强组织适应性。这些涂层材料可通过简单的物理或化学方法在PLGA表面进行修饰，且涂覆多种材料可同时赋予PLGA支架不同的功能；这不仅能确保更强的细胞黏附，还能调节细胞行为和功能。这种涂层方法有助于生产更多基于PLGA的细胞支架。本综述聚焦于PLGA表面改性材料、方法及应用，将为PLGA表面改性提供指导。
