Xu Zhixiong, Xu Wensheng, Zhang Tao, Luo Long
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
J Orthop Surg Res. 2024 Dec 3;19(1):817. doi: 10.1186/s13018-024-05304-8.
The healing of tendon-bone contact surfaces involves complex biomechanical and biochemical interactions, with pivotal implications for sports medicine and rehabilitation. This review explores applications from cellular mechanics to tissue engineering, emphasizing how biomechanics impact tendon-bone healing. Cells regulate behavior, including growth, differentiation, and migration, by sensing mechanical signals and translating them into biochemical responses, which are critical in the healing process. Cellular mechanics modulate intracellular signaling, thereby influencing biological function and healing capacity. Optimizing tendon-bone interface repair involves modulating the extracellular mechanical environment. This includes physical stimulation, such as stretching, pressure, or vibration, to promote cellular alignment and enhance tissue structural integrity. Tissue engineering in tendon-bone healing focuses on designing scaffolds that mimic the biomechanical properties of the natural tendon-bone interface. Synthesizing these studies provides an in-depth understanding and utilization of biomechanical principles, significantly improving tendon-bone healing and offering new directions for clinical treatments to achieve better therapeutic outcomes and rehabilitation for patients with sports injuries.
肌腱与骨接触面的愈合涉及复杂的生物力学和生物化学相互作用，对运动医学和康复具有关键意义。本综述探讨了从细胞力学到组织工程的应用，强调了生物力学如何影响肌腱与骨的愈合。细胞通过感知机械信号并将其转化为生化反应来调节行为，包括生长、分化和迁移，这在愈合过程中至关重要。细胞力学调节细胞内信号传导，从而影响生物学功能和愈合能力。优化肌腱与骨界面修复涉及调节细胞外机械环境。这包括物理刺激，如拉伸、压力或振动，以促进细胞排列并增强组织结构完整性。肌腱与骨愈合中的组织工程专注于设计模仿天然肌腱与骨界面生物力学特性的支架。综合这些研究能够深入理解和运用生物力学原理，显著改善肌腱与骨的愈合，并为临床治疗提供新方向，从而为运动损伤患者实现更好的治疗效果和康复。
