Students' Scientific Association at the Department of Histology, Embryology and Cytophysiology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.
Department of Histology, Embryology and Cytophysiology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.
Nutrients. 2023 Dec 21;16(1):37. doi: 10.3390/nu16010037.
The aim of this study was to assess the influence of bee pollen supplementation on the levels of enzymes important for gastric mucosal homeostasis, namely cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and a biomarker-asymmetric dimethylarginine (ADMA)-in the gastric mucosa of Wistar rats. The experimental phase divided the rats into four groups: two control groups, sedentary and active, both not supplemented, and two experimental groups, sedentary and active, supplemented with bee pollen. The results indicated that bee pollen supplementation reduced the levels of COX-1 and elevated iNOS levels, while showing no significant impact on COX-2 levels. These findings do not conclusively support the gastroprotective and anti-inflammatory effects of bee pollen on gastric mucosa. However, the supplementation could have resulted in reduced ADMA levels in the physically active supplemented group. Our study does not unequivocally demonstrate the positive effects of bee pollen supplementation on the gastric mucosa, which may be attributed to the specific metabolism and bioavailability of substances within unprocessed, dried bee pollen. Further research should explore the topic of potential therapeutic applications of bee pollen in gastrointestinal health and its interactions with ADMA signaling pathways.
本研究旨在评估蜂花粉补充对胃黏膜稳态重要酶水平的影响，即环氧化酶-1（COX-1）、环氧化酶-2（COX-2）、诱导型一氧化氮合酶（iNOS）和胃黏膜生物标志物——不对称二甲基精氨酸（ADMA）。实验阶段将大鼠分为四组：两组对照组，不运动和运动，均不补充；两组实验组，不运动和运动，补充蜂花粉。结果表明，蜂花粉补充降低了 COX-1 水平，升高了 iNOS 水平，而对 COX-2 水平没有显著影响。这些发现并不完全支持蜂花粉对胃黏膜具有胃保护和抗炎作用。然而，补充可能导致活跃补充组 ADMA 水平降低。我们的研究并没有明确证明蜂花粉补充对胃黏膜的积极影响，这可能归因于未经加工、干燥的蜂花粉中物质的特定代谢和生物利用度。进一步的研究应探讨蜂花粉在胃肠道健康中的潜在治疗应用及其与 ADMA 信号通路相互作用的问题。
