Trovato Chiara Maria, Ferretti Francesca, Delli Bovi Anna Pia, Elefante Giovanna, Ancinelli Monica, Bolasco Giulia, Capriati Teresa, Cardile Sabrina, Knafelz Daniela, Bracci Fiammetta, Alterio Arianna, Malamisura Monica, Grosso Salvatore, De Angelis Paola, Diamanti Antonella
Nutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Clinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, 53100 Siena, Italy.
Nutrients. 2024 Dec 31;17(1):129. doi: 10.3390/nu17010129.
BACKGROUND/OBJECTIVES: In Italy, the prevalence of celiac disease (CeD) among children exceeds 1.5% and has steadily increased with a linear trend over the past 25 years. The clinical presentation is heterogenous and a change in onset symptoms has been described in recent years. The aim of the study is to describe the pattern of clinical presentation of CeD during the last 12 years in a single Italian center.
We retrospectively enrolled all children diagnosed with CeD at Bambino Gesù Children Hospital, Rome between 1 March 2011 and 22 June 2023. To investigate the changes in pattern of clinical presentation, we divided the patient population into three groups of approximately 4 years each (respectively: 49, 48 and 48 months). Patients who previously received a CeD diagnosis in other centers were excluded.
Overall, 4478 patients were diagnosed with CeD at our center. 1082 were excluded, leaving 3396 available for analysis. We divided the study cohort into three groups: group 1 ( = 909), group 2 ( = 1103), and group 3 ( = 1384). Diagnoses of CeD increased by 17.5%. The trend of the non-classic form shows a significative increase ( = 0.000064), showing a high prevalence of bloating and abdominal pain and a significant reduction in celiac crisis ( < 0.0001).
Annual diagnoses of CeD increased during the study period, and the clinical presentation has changed in recent years, showing an increase in the non-classic form and a reduction in more severe forms of celiac crisis.
背景/目的：在意大利，儿童乳糜泻（CeD）的患病率超过1.5%，并且在过去25年中呈线性趋势稳步上升。其临床表现具有异质性，近年来发病症状有所变化。本研究的目的是描述在意大利的一个单一中心中，过去12年里CeD的临床表现模式。
我们回顾性纳入了2011年3月1日至2023年6月22日期间在罗马的 Bambino Gesù儿童医院被诊断为CeD的所有儿童。为了研究临床表现模式的变化，我们将患者群体分为三组，每组约4年（分别为：49、48和48个月）。排除先前在其他中心被诊断为CeD的患者。
总体而言，我们中心有4478例患者被诊断为CeD。排除1082例，剩余3396例可供分析。我们将研究队列分为三组：第1组（= 909）、第2组（= 1103）和第3组（= 1384）。CeD的诊断增加了17.5%。非典型形式的趋势显示出显著增加（= 0.000064），腹胀和腹痛的患病率较高，乳糜泻危象显著减少（< 0.0001）。
在研究期间，CeD的年度诊断有所增加，并且近年来临床表现发生了变化，非典型形式增加，更严重的乳糜泻危象形式减少。
