Freeman Morgan, Lally Lauren, Teigen Levi, Graziano Elliot, Shivashankar Raina, Shmidt Eugenia
Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN 55455, USA.
Division of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
J Clin Med. 2023 Dec 23;13(1):88. doi: 10.3390/jcm13010088.
(1) Background: There are limited data available to guide clinical decision-making regarding the effects of hormone replacement therapy (HRT) in post-menopausal women with inflammatory bowel disease (IBD). In this study, we sought to characterize a population of post-menopausal women with IBD and to determine the effects of HRT on their disease activity. (2) Methods: A multicenter, retrospective, case-control cohort study of post-menopausal women with IBD was conducted. The physician global assessment (PGA) score was used to quantify disease activity. To control for the effects of menopause, IBD patients who had not undergone HRT were used as controls. (3) Results: There was a significant reduction in the frequency of PGA scores ≥2 post HRT treatment ( < 0.01). HRT treatment was associated with a 5.6× increase in the odds of post-HRT PGA score improvement compared to controls (OR 5.6; 95% CL 1.6, 19.7) in our univariate logistic regression analysis. (4) Conclusion: Post-menopausal IBD women who underwent HRT therapy showed an improvement in their disease symptoms following HRT compared to post-menopausal women without HRT therapy, who showed no change.
(1) 背景：关于激素替代疗法（HRT）对绝经后炎症性肠病（IBD）女性的影响，可用于指导临床决策的数据有限。在本研究中，我们试图描述绝经后IBD女性群体的特征，并确定HRT对其疾病活动的影响。(2) 方法：对绝经后IBD女性进行了一项多中心、回顾性、病例对照队列研究。采用医生整体评估（PGA）评分来量化疾病活动。为了控制绝经的影响，未接受HRT的IBD患者被用作对照。(3) 结果：HRT治疗后PGA评分≥2的频率显著降低（<0.01）。在我们的单因素逻辑回归分析中，与对照组相比，HRT治疗使HRT后PGA评分改善的几率增加了5.6倍（OR 5.6；95% CL 1.6，19.7）。(4) 结论：与未接受HRT治疗且症状无变化的绝经后女性相比，接受HRT治疗的绝经后IBD女性在HRT后疾病症状有所改善。
