Department of Gastroenterology, Affiliated Hospital, Zunyi Medical College, 149 Dalian Road, Zunyi, 563003, China.
Dig Dis Sci. 2018 Mar;63(3):583-596. doi: 10.1007/s10620-018-4939-1. Epub 2018 Jan 31.
Estrogen is a kind of steroid compound that has extensive biologic activities. The effect of estrogen is pleiotropic, affecting multiple systems in the body. There is accumulating evidence that estrogen has important effects on the gastrointestinal tract. Longer exposure to estrogen may decrease the risk of gastric cancer. Use of the anti-estrogen drug tamoxifen might increase the risk of gastric adenocarcinoma. Estrogen receptor β may serve as a target for colorectal cancer prevention. In addition, estrogen has been reported to be closely related to the mucosal barrier, gastrointestinal function and intestinal inflammation. However, the role of estrogen in the gastrointestinal tract has not been systematically summarized. In this review, we aim to provide an overview of the role of estrogen in the gastrointestinal tract and evaluate it from various aspects, including estrogen receptors, the mucosal barrier, intestinal inflammation and gastrointestinal tract tumors, which may provide the basis for the development of therapeutic strategies to manage gastrointestinal diseases.
雌激素是一种具有广泛生物活性的甾体化合物。雌激素的作用是多效的，影响着体内的多个系统。有越来越多的证据表明，雌激素对胃肠道有重要作用。更长时间的雌激素暴露可能会降低胃癌的风险。使用抗雌激素药物他莫昔芬可能会增加胃腺癌的风险。雌激素受体β可能是预防结直肠癌的靶点。此外，雌激素已被报道与黏膜屏障、胃肠功能和肠道炎症密切相关。然而，雌激素在胃肠道中的作用尚未得到系统总结。在这篇综述中，我们旨在概述雌激素在胃肠道中的作用，并从雌激素受体、黏膜屏障、肠道炎症和胃肠道肿瘤等多个方面对其进行评估，这可能为开发治疗胃肠道疾病的治疗策略提供依据。
