东亚人群中身高较高者患膝关节骨关节炎的风险降低：一项全国性队列研究。

Decreased Risk of Knee Osteoarthritis with Taller Height in an East Asian Population: A Nationwide Cohort Study.

作者信息

Lee Dong Hwan, Lee Hwa Sung, Jang Soo Hyun, Heu Jun-Young, Han Kyungdo, Lee Se-Won

机构信息

Department of Orthopedic Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-Ro, Seoul 07345, Republic of Korea.

Department of Orthopedic Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-ro, Incheon 21431, Republic of Korea.

出版信息

J Clin Med. 2023 Dec 23;13(1):92. doi: 10.3390/jcm13010092.

DOI:10.3390/jcm13010092

PMID:38202099

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10779701/

Abstract

BACKGROUND

Numerous studies have explored factors impacting osteoarthritis (OA), but its relationship with height remains uncertain. This study investigates the relationship between height and osteoarthritis risk in South Korea.

METHODS

Participants aged 50 or older who underwent health screenings in 2009 were selected from the National Health Insurance System database. A total of 1,138,904 subjects were divided into height quartiles (Q1-Q4) based on age and gender. Cox proportional hazard models were used to assess knee osteoarthritis incidence risk, with the shortest quartile (Q1) as the reference.

RESULTS

After adjusting for age, sex, income, smoking, drinking, exercise, hypertension, diabetes mellitus, dyslipidemia, and body mass index (BMI), no significant difference in OA incidence risk based on height was observed. However, when adjusted for weight instead of BMI, we observed a gradual decrease in hazard ratio with increasing height. The hazard ratio for the tallest group was 0.787 (95% CI, 0.781~0.795). Similar results were obtained in all subgroups.

CONCLUSIONS

Compared to previous studies, our findings present a clear distinction. Therefore, there may be racial differences in the association between height and knee OA risk, and our study provides evidence that, in East Asian populations, taller individuals have a reduced risk of knee OA.

摘要

背景

众多研究探讨了影响骨关节炎（OA）的因素，但其与身高的关系仍不明确。本研究调查了韩国身高与骨关节炎风险之间的关系。

方法

从国民健康保险系统数据库中选取2009年接受健康筛查的50岁及以上参与者。根据年龄和性别将总共1,138,904名受试者分为身高四分位数组（Q1-Q4）。采用Cox比例风险模型评估膝关节骨关节炎的发病风险，以最短四分位数组（Q1）作为参照。

结果

在调整年龄、性别、收入、吸烟、饮酒、运动、高血压、糖尿病、血脂异常和体重指数（BMI）后，未观察到基于身高的OA发病风险存在显著差异。然而，当用体重而非BMI进行调整时，我们观察到随着身高增加风险比逐渐降低。最高组的风险比为0.787（95%CI，0.781~0.795）。在所有亚组中均获得类似结果。