Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
Department of Medicine, Graduate School of Medicine, Yonsei University, Seoul, Korea.
Geriatr Gerontol Int. 2020 Apr;20(4):379-383. doi: 10.1111/ggi.13879. Epub 2020 Feb 9.
To investigate the relationship between knee osteoarthritis, mental health and health-related quality of life (QoL).
This study included 6343 men and women aged ≥50 years from the Korean National Health and Nutrition Examination Survey. Osteoarthritis was defined as Kellgren-Lawrence grade ≥2 in the knee on radiographic images with knee pain. Mental health and health-related QoL were assessed according to three dimensions (depressive mood, psychological distress and suicidal ideation) and five domains (impaired mobility, impaired self-care, impaired usual activities, pain/discomfort and anxiety/depression). The odds ratios and 95% confidence intervals (CI) for mental health and health-related QoL were calculated using multiple logistic regression analyses.
Compared with the control group, the odds ratios for depressive mood, psychological distress and suicidal ideation in the osteoarthritis group were 2.80 (95% CI 1.31-3.31), 1.92 (95% CI 1.21-3.05) and 1.97 (95% CI 1.31-2.94) in men, and 1.51 (95% CI 1.16-1.95), 1.36 (95% CI 1.07-1.72) and 1.92 (95% CI 1.49-2.46) in women after adjusting for potential confounding variables. Similarly, the odds ratios for impaired mobility, impaired self-care, impaired usual activities, pain/discomfort and anxiety/depression in the osteoarthritis group were 12.37 (95% CI 8.17-18.72), 3.02 (95% CI 1.84-4.94), 7.33 (95% CI 4.89-10.98), 8.92 (95% CI 5.92-13.45) and 2.56 (95% CI 1.52-4.29) in men, and 8.29 (95% CI 6.41-10.73), 2.53 (95% CI 1.74-3.69), 4.40 (95% CI 3.33-5.80), 4.79 (95% CI 3.72-6.17) and 1.85 (1.44-2.37) in women after adjusting for the same covariables.
Knee osteoarthritis was significantly associated with deteriorated mental health and health-related QoL in middle-aged and older men and women. Geriatr Gerontol Int 2020; 20: 379-383.
探讨膝骨关节炎与心理健康和健康相关生活质量（QoL）之间的关系。
本研究纳入了韩国国家健康和营养检查调查中 6343 名年龄≥50 岁的男性和女性。骨关节炎的定义为膝关节放射影像上的 Kellgren-Lawrence 分级≥2 级，并伴有膝关节疼痛。根据三个维度（抑郁情绪、心理困扰和自杀意念）和五个领域（活动受限、自我护理受限、日常活动受限、疼痛/不适和焦虑/抑郁）评估心理健康和健康相关 QoL。采用多因素逻辑回归分析计算心理健康和健康相关 QoL 的比值比（OR）和 95%置信区间（CI）。
与对照组相比，男性骨关节炎组的抑郁情绪、心理困扰和自杀意念的 OR 值分别为 2.80（95%CI 1.31-3.31）、1.92（95%CI 1.21-3.05）和 1.97（95%CI 1.31-2.94），女性分别为 1.51（95%CI 1.16-1.95）、1.36（95%CI 1.07-1.72）和 1.92（95%CI 1.49-2.46）。调整潜在混杂变量后，男性骨关节炎组活动受限、自我护理受限、日常活动受限、疼痛/不适和焦虑/抑郁的 OR 值分别为 12.37（95%CI 8.17-18.72）、3.02（95%CI 1.84-4.94）、7.33（95%CI 4.89-10.98）、8.92（95%CI 5.92-13.45）和 2.56（95%CI 1.52-4.29），女性分别为 8.29（95%CI 6.41-10.73）、2.53（95%CI 1.74-3.69）、4.40（95%CI 3.33-5.80）、4.79（95%CI 3.72-6.17）和 1.85（1.44-2.37）。
在中年和老年男性和女性中，膝骨关节炎与心理健康和健康相关 QoL 恶化显著相关。
