天然植物、药物、环境和生物样本中马兜铃酸的检测与去除：综述。

School of Environmental Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.

College of Geography and Environment, Shandong Normal University, Jinan 250000, China.

Molecules. 2023 Dec 22;29(1):81. doi: 10.3390/molecules29010081.

Aristolochic acids (AAs) are a toxic substance present in certain natural plants. Direct human exposure to these plants containing AAs leads to a severe and irreversible condition known as aristolochic acid nephropathy (AAN). Additionally, AAs accumulation in the food chain through environmental mediators can trigger Balkan endemic nephropathy (BEN), an environmental variant of AAN. This paper presents a concise overview of the oncogenic pathways associated with AAs and explores the various routes of environmental exposure to AAs. The detection and removal of AAs in natural plants, drugs, and environmental and biological samples were classified and summarized, and the advantages and disadvantages of the various methods were analyzed. It is hoped that this review can provide effective insights into the detection and removal of AAs in the future.

马兜铃酸（AAs）是存在于某些天然植物中的一种有毒物质。人类直接接触含有 AAs 的这些植物会导致一种严重且不可逆转的疾病，称为马兜铃酸肾病（AAN）。此外，AAs 通过环境介质在食物链中的积累会引发巴尔干地方性肾病（BEN），这是 AAN 的一种环境变异。本文简要概述了与 AAs 相关的致癌途径，并探讨了环境中接触 AAs 的各种途径。对天然植物、药物、环境和生物样本中 AAs 的检测和去除进行了分类和总结，并分析了各种方法的优缺点。希望本文的综述能够为未来 AAs 的检测和去除提供有效的见解。