Department of Orthopaedics and Traumatology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Praxis Dr. Med. Univ. Alexander Wurm FA für Orthopädie und Traumatologie, Koflerweg 7, 6275 Stumm, Austria.
Int J Mol Sci. 2023 Dec 30;25(1):541. doi: 10.3390/ijms25010541.
Osteomyelitis is a bone disease caused by bacteria that can damage bone. Raman handheld spectroscopy has emerged as a promising diagnostic tool for detecting bone infection and can be used intraoperatively during surgical procedures. This study involved 120 bone samples from 40 patients, with 80 samples infected with either or Raman handheld spectroscopy demonstrated successful differentiation between healthy and infected bone samples and between the two types of bacterial pathogens. Raman handheld spectroscopy appears to be a promising diagnostic tool in bone infection and holds the potential to overcome many of the shortcomings of traditional diagnostic procedures. Further research, however, is required to confirm its diagnostic capabilities and consider other factors, such as the limit of pathogen detection and optimal calibration standards.
骨髓炎是一种由细菌引起的骨骼疾病，可导致骨骼受损。手持式拉曼光谱技术已成为一种很有前途的诊断工具，可用于检测骨感染，并可在手术过程中进行术中使用。本研究涉及 40 名患者的 120 个骨样本，其中 80 个样本感染了 或 。手持式拉曼光谱技术成功地区分了健康和感染的骨样本以及两种类型的细菌病原体。手持式拉曼光谱技术似乎是一种很有前途的骨感染诊断工具，有可能克服传统诊断程序的许多缺点。然而，需要进一步的研究来确认其诊断能力，并考虑其他因素，例如病原体检测的极限和最佳校准标准。
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