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甘肃高山细毛羊羊毛发育和细度相关长链非编码RNA的筛选

Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep.

作者信息

He Zhaohua, Zhao Fangfang, Sun Hongxian, Hu Jiang, Wang Jiqing, Liu Xiu, Li Mingna, Hao Zhiyun, Zhao Zhidong, Shi Bingang, Liu Feiyan, Li Shaobin

机构信息

Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, 730070, China.

Animal Husbandry and Veterinary Station, Weiyuan County, Luyuan Township, Dingxi, 748200, China.

出版信息

BMC Genomics. 2025 Jan 6;26(1):8. doi: 10.1186/s12864-024-11195-0.

DOI:10.1186/s12864-024-11195-0
PMID:39762742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11702032/
Abstract

Wool growth and fineness regulation is influenced by some factors such as genetics and environment. At the same time, lncRNA participates in numerous biological processes in animal production. In this research, we conducted a thorough analysis and characterization of the microstructure of wool, along with long non-coding RNAs (lncRNAs), their target genes, associated pathways, and Gene Ontology terms pertinent to the wool fineness development. The investigation utilized scanning electron microscopy and transcriptomic technology, focusing on two distinct types in Gansu alpine fine-wool sheep: coarse type (group C, MFD = 22.26 ± 0.69 μm, n = 6) and fine type (group F, MFD = 16.91 ± 0.29 μm, n = 6), which exhibit differing wool fiber diameters. The results showed that fine type wool fiber scales were more regularly distributed in rings with large scale spacing and smooth edges, while coarse type wool fiber scales were more irregularly arranged in tiles with relatively rougher edges, and the density of wool scales was greater than that of fine type wool. Furthermore, a comprehensive analysis revealed 164 differentially expressed lncRNAs along with 146 potential target genes linked to these lncRNAs in the skin tissues from groups C and F. Utilizing functional enrichment analysis on the target genes, we successfully identified a number of target genes might be associated with the improvement of wool fineness, such as FOXN1, LIPK, LOC101116068, LOC101106296, KRTAP5.4, KRT71, KRT82, DNASE1L2, which are related to hair follicle development, histidine metabolism, epidermal cell differentiation, oxidative phosphorylation and hair cycle process. Additionally, the interoperability network involving lncRNAs-mRNAs indicated lncRNAs (MSTRG.17445.2, XR_006060725.1, MSTRG.871.1, MSTRG.10907.4) might play a significant role in the wool growth development and fineness improvement process. In conclusion, the research enlarges the current lncRNAs database, providing a new insight for the investigation of wool fineness development in fine-wool sheep.

摘要

羊毛生长和细度调控受遗传和环境等多种因素影响。同时，长链非编码RNA（lncRNA）参与动物生产中的众多生物学过程。在本研究中，我们对羊毛的微观结构以及长链非编码RNA（lncRNA）、其靶基因、相关途径和与羊毛细度发育相关的基因本体术语进行了全面分析和表征。该研究利用扫描电子显微镜和转录组技术，聚焦甘肃高山细毛羊的两种不同类型：粗毛型（C组，平均纤维直径MFD = 22.26 ± 0.69μm，n = 6）和细毛型（F组，MFD = 16.91 ± 0.29μm，n = 6），这两种类型的羊毛纤维直径不同。结果表明，细毛型羊毛纤维鳞片呈环状分布更规则，鳞片间距大且边缘光滑，而粗毛型羊毛纤维鳞片呈瓦片状排列更不规则，边缘相对粗糙，且羊毛鳞片密度大于细毛型羊毛。此外，综合分析显示，C组和F组皮肤组织中有164个差异表达的lncRNA以及146个与这些lncRNA相关的潜在靶基因。通过对靶基因进行功能富集分析，我们成功鉴定出一些可能与羊毛细度改善相关的靶基因，如FOXN1、LIPK、LOC101116068、LOC101106296、KRTAP5.4、KRT71、KRT82、DNASE1L2，它们与毛囊发育、组氨酸代谢、表皮细胞分化、氧化磷酸化和毛发周期过程有关。此外，lncRNAs - mRNAs互作网络表明lncRNAs（MSTRG.17445.2、XR_006060725.1、MSTRG.871.1、MSTRG.10907.4）可能在羊毛生长发育和细度改善过程中发挥重要作用。总之，该研究扩展了当前的lncRNAs数据库，为细毛羊羊毛细度发育的研究提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8d/11702032/44e0f72f2ad5/12864_2024_11195_Fig8_HTML.jpg
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