Shixiong Zhang, Shaowei Liu, Zeqi Yang, Miaochan Xu, Pingping Zhou, Haiyan Bai, Jingjing Lv, Yangang Wang
Nanjing University of Chinese Medicine, Nanjing 210046, China.
Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Int J Anal Chem. 2024 Jan 2;2024:6684677. doi: 10.1155/2024/6684677. eCollection 2024.
According to traditional Chinese medicine theory, tongue coatings reflect changes in the body. The goal of this study was to identify a metabolite or a set of metabolites capable of classifying characteristics of traditional Chinese medicine syndromes in erosive gastritis. In this study, we collected tongue coatings of patients with erosive gastritis with damp-heat syndrome (DHS), liver depression and qi stagnation syndrome (LDQSS), and healthy volunteers. Then, we analyzed the differences in metabolic characteristics between the two groups based on metabolomics. We identified 14 potential biomarkers related to the DHS group, and six metabolic pathways were enriched. The differential pathways included pyrimidine metabolism, pantothenate and CoA biosynthesis, citrate cycle (TCA cycle), pyruvate metabolism, glycolysis/gluconeogenesis, and purine metabolism. Similarly, in the LDQSS group, we identified 25 potential biomarkers and 18 metabolic pathways were enriched. The top five pathways were the TCA cycle, sphingolipid metabolism, fatty acid biosynthesis, pantothenate and CoA biosynthesis, and the pentose phosphate pathway. In conclusion, the DHS group and the LDQSS group have different characteristics.
根据中医理论，舌苔反映人体的变化。本研究的目的是鉴定一种或一组能够对糜烂性胃炎的中医证候特征进行分类的代谢物。在本研究中，我们收集了患有湿热证（DHS）、肝郁气滞证（LDQSS）的糜烂性胃炎患者以及健康志愿者的舌苔。然后，我们基于代谢组学分析了两组之间代谢特征的差异。我们鉴定出了14种与DHS组相关的潜在生物标志物，并富集了6条代谢途径。差异途径包括嘧啶代谢、泛酸和辅酶A生物合成、柠檬酸循环（TCA循环）、丙酮酸代谢、糖酵解/糖异生以及嘌呤代谢。同样，在LDQSS组中，我们鉴定出了25种潜在生物标志物，并富集了18条代谢途径。排名前五的途径是TCA循环、鞘脂代谢、脂肪酸生物合成、泛酸和辅酶A生物合成以及磷酸戊糖途径。总之，DHS组和LDQSS组具有不同的特征。
