Roberts W N, Liang M H, Stern S H
JAMA. 1987 Apr 10;257(14):1920-2.
Colchicine is an effective and relatively specific treatment for acute gout and has a long, venerable history. Serious toxic reactions to colchicine could be prevented if guidelines for its use were followed strictly, but because of its relatively infrequent use and conflicting recommendations, considerable toxic effects might occur and still be undetected by passive surveillance. A review of a teaching hospital's four years' experience showed two deaths (2% incidence) due to inappropriate use. Colchicine has the smallest benefit-to-toxicity ratio of drugs that are effective for acute gout. This article gives specific recommendations for the use of colchicine in different clinical settings.
秋水仙碱是治疗急性痛风的一种有效且相对特异的药物，其历史悠久且备受尊崇。如果严格遵循秋水仙碱的使用指南，对其严重的毒性反应是可以预防的，但由于其使用相对不频繁且存在相互矛盾的推荐意见，可能会出现相当多的毒性作用，而被动监测仍可能无法察觉。对一家教学医院四年经验的回顾显示，因使用不当导致了两例死亡（发生率为2%）。秋水仙碱在对急性痛风有效的药物中，其效益 - 毒性比最小。本文给出了在不同临床环境下使用秋水仙碱的具体建议。
