Ahern M J, Reid C, Gordon T P, McCredie M, Brooks P M, Jones M
Department of Medicine, Flinders University of South Australia.
Aust N Z J Med. 1987 Jun;17(3):301-4. doi: 10.1111/j.1445-5994.1987.tb01232.x.
We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two-thirds of colchicine-treated patients improved after 48 hours, but only one-third of the patients receiving placebo demonstrated similar improvement. The colchicine-treated patients responded earlier; significant differences from placebo were shown after 18-30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.
我们开展了第一项关于秋水仙碱治疗急性痛风的对照研究，以确定其疗效和毒性，并明确急性痛风的自然病程。接受秋水仙碱治疗的患者中有三分之二在48小时后病情改善，但接受安慰剂治疗的患者中只有三分之一表现出类似改善。接受秋水仙碱治疗的患者反应更早；在18 - 30小时后与安慰剂组出现显著差异。所有服用秋水仙碱的患者在中位时间24小时后（秋水仙碱平均剂量6.7毫克）出现腹泻。在大多数患者中，这种副作用在疼痛缓解之前就出现了。
