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一例罕见的男性浸润性导管癌在辅助治疗不完全后出现新转移的弛张热病例。

A Rare Case of Remittent Male Invasive Ductal Carcinoma With New Metastasis After Incomplete Adjuvant Therapy.

作者信息

Mada Sanjana R, Zay Hein H, Bies Jared J, Massebo Eyoab, Didia Claudia

机构信息

Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA.

出版信息

Cureus. 2023 Dec 12;15(12):e50400. doi: 10.7759/cureus.50400. eCollection 2023 Dec.

Abstract

Breast cancer is a rare disease in men with many barriers to effective management such as limited research and treatment modalities. While the current standard of care utilizes mastectomy and axillary dissection with chemotherapy, clinicians must follow the female-staged breast cancer protocol, as there is no established regimen for men. In this case presentation, we report a 43-year-old male with a prior history of ER-positive invasive ductal carcinoma (IDC) who presented with a recurrent breast lesion. The patient had previously undergone left breast mastectomy with sentinel node biopsy with negative margins. The patient declined adjuvant chemotherapy and tamoxifen therapy after the initial dissection. Three years after the primary dissection, the patient presents with a breast lesion and metastasis to bilateral axillary lymph nodes, lungs, and spine. The diagnosis was supported by a right axillary biopsy which revealed an ER-positive and PR-positive lesion. We want to shed light on the importance of complete and thorough treatment of primary IDC in men while highlighting the implications of incomplete treatment. We hope that this clinical case will serve as a guide for physicians in promoting adjuvant treatments after primary tumor removal in male IDC.

摘要

乳腺癌在男性中是一种罕见疾病,有效治疗存在诸多障碍,如研究有限和治疗方式单一。虽然目前的护理标准采用乳房切除术和腋窝淋巴结清扫术并辅以化疗,但临床医生必须遵循女性分期乳腺癌治疗方案,因为尚无针对男性的既定治疗方案。在本病例报告中,我们报道了一名43岁男性,既往有雌激素受体(ER)阳性浸润性导管癌(IDC)病史,此次因复发性乳腺病变前来就诊。该患者此前接受了左侧乳房切除术及前哨淋巴结活检,切缘阴性。初次手术后,患者拒绝辅助化疗和他莫昔芬治疗。初次手术后三年,患者出现乳腺病变,并转移至双侧腋窝淋巴结、肺部和脊柱。右腋窝活检显示为ER阳性和孕激素受体(PR)阳性病变,支持了诊断。我们希望阐明男性原发性IDC彻底治疗的重要性,同时强调不完全治疗的影响。我们希望这个临床病例能为医生在男性IDC原发性肿瘤切除后推广辅助治疗提供指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e6/10783793/7a4d8314aaee/cureus-0015-00000050400-i01.jpg

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