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具有成骨特性的聚乳酸-磷酸三钙-二氧化铈3D打印生物可吸收复合支架用于骨再生

3D printed bioabsorbable composite scaffolds of poly (lactic acid)-tricalcium phosphate-ceria with osteogenic property for bone regeneration.

作者信息

Harb Samarah V, Kolanthai Elayaraja, Pugazhendhi Abinaya S, Beatrice Cesar A G, Pinto Leonardo A, Neal Craig J, Backes Eduardo H, Nunes Ana C C, Selistre-de-Araújo Heloisa S, Costa Lidiane C, Coathup Melanie J, Seal Sudipta, Pessan Luiz A

机构信息

Department of Materials Engineering (DEMa), Federal University of Sao Carlos (UFSCar), São Carlos, SP, Brazil.

Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering, University of Central Florida, Orlando, FL, USA.

出版信息

Biomater Biosyst. 2023 Dec 18;13:100086. doi: 10.1016/j.bbiosy.2023.100086. eCollection 2024 Mar.

DOI:10.1016/j.bbiosy.2023.100086
PMID:38213985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10776431/
Abstract

The fabrication of customized implants by additive manufacturing has allowed continued development of the personalized medicine field. Herein, a 3D-printed bioabsorbable poly (lactic acid) (PLA)- β-tricalcium phosphate (TCP) (10 wt %) composite has been modified with CeO nanoparticles (CeNPs) (1, 5 and 10 wt %) for bone repair. The filaments were prepared by melt extrusion and used to print porous scaffolds. The nanocomposite scaffolds possessed precise structure with fine print resolution, a homogenous distribution of TCP and CeNP components, and mechanical properties appropriate for bone tissue engineering applications. Cell proliferation assays using osteoblast cultures confirmed the cytocompatibility of the composites. In addition, the presence of CeNPs enhanced the proliferation and differentiation of mesenchymal stem cells; thereby, increasing alkaline phosphatase (ALP) activity, calcium deposition and bone-related gene expression. Results from this study have shown that the 3D printed PLA-TCP-10%CeO composite scaffold could be used as an alternative polymeric implant for bone tissue engineering applications: avoiding additional/revision surgeries and accelerating the regenerative process.

摘要

通过增材制造定制植入物推动了个性化医疗领域的持续发展。在此，一种3D打印的可生物吸收聚乳酸（PLA）-β-磷酸三钙（TCP）（10 wt%）复合材料已用CeO纳米颗粒（CeNPs）（1、5和10 wt%）进行改性以用于骨修复。这些长丝通过熔融挤出制备，并用于打印多孔支架。纳米复合支架具有精确的结构、良好的打印分辨率、TCP和CeNP成分的均匀分布以及适合骨组织工程应用的机械性能。使用成骨细胞培养的细胞增殖试验证实了复合材料的细胞相容性。此外 CeNPs 的存在增强了间充质干细胞的增殖和分化；从而增加碱性磷酸酶（ALP）活性、钙沉积和骨相关基因表达。这项研究的结果表明 3D 打印的 PLA-TCP-10%CeO 复合支架可作为骨组织工程应用的替代聚合物植入物：避免额外/翻修手术并加速再生过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/4cf425b041fe/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/69a93591ac5a/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/5c90c1a0fc1e/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/e39ee581dbb2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/105552833a65/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/6563299dd7b4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/4cf425b041fe/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/69a93591ac5a/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/5c90c1a0fc1e/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/e39ee581dbb2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/105552833a65/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/6563299dd7b4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10776431/4cf425b041fe/gr4.jpg

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