Materials Engineering Department, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, São Carlos, Brazil.
Science and Technology Institute, Federal University of São Paulo, São Paulo, Brazil.
J Biomed Mater Res B Appl Biomater. 2022 Jun;110(6):1479-1503. doi: 10.1002/jbm.b.34997. Epub 2021 Dec 17.
Polycaprolactone (PCL) has been extensively applied on tissue engineering because of its low-melting temperature, good processability, biodegradability, biocompatibility, mechanical resistance, and relatively low cost. The advance of additive manufacturing (AM) technologies in the past decade have boosted the fabrication of customized PCL products, with shorter processing time and absence of material waste. In this context, this review focuses on the use of AM techniques to produce PCL scaffolds for various tissue engineering applications, including bone, muscle, cartilage, skin, and cardiovascular tissue regeneration. The search for optimized geometry, porosity, interconnectivity, controlled degradation rate, and tailored mechanical properties are explored as a tool for enhancing PCL biocompatibility and bioactivity. In addition, rheological and thermal behavior is discussed in terms of filament and scaffold production. Finally, a roadmap for future research is outlined, including the combination of PCL struts with cell-laden hydrogels and 4D printing.
聚己内酯（PCL）由于其低熔点、良好的加工性、可生物降解性、生物相容性、机械强度和相对较低的成本，已被广泛应用于组织工程领域。在过去十年中，增材制造（AM）技术的进步推动了定制 PCL 产品的制造，其加工时间更短，且不存在材料浪费。在这种背景下，本综述重点介绍了使用 AM 技术来生产用于各种组织工程应用的 PCL 支架，包括骨、肌肉、软骨、皮肤和心血管组织再生。探索了优化几何形状、孔隙率、连通性、控制降解率和定制机械性能的方法，以提高 PCL 的生物相容性和生物活性。此外，还讨论了在纤维和支架生产方面的流变学和热行为。最后，概述了未来研究的路线图，包括 PCL 支柱与细胞负载水凝胶和 4D 打印的结合。
