Department of Psychology, University of Wisconsin - Milwaukee, Milwaukee, WI, USA.
Mental Health Department, Kaiser Permanente, Portland, OR, USA.
Child Neuropsychol. 2024 Aug;30(6):938-953. doi: 10.1080/09297049.2024.2302634. Epub 2024 Jan 12.
The present study investigated the performance of children with neurofibromatosis type 1 on computerized assessments of attention and executive function. Relations to ADHD symptomatology were also examined. Participants included 37 children (20 male) with NF1 (9-13 years; M = 11.02). Participants completed the NIH Toolbox Dimensional Change Card Sort, List Sort Working Memory (LSWM), and Flanker tasks, as well as Cogstate Identification and One Back tests. ADHD symptomatology was assessed using the K-SADS. Average performance was significantly different from the normative mean on every measure, except LSWM. The NIH Toolbox Flanker and Cogstate Identification tasks detected the highest proportion of participants with at least mild difficulty, and the Cogstate Identification task detected the highest proportion of participants with severe difficulty. Analyses revealed significant relations with ADHD symptomatology for two NIH toolbox tasks. The various computerized measures of attention and executive function offer different information when working with school age children with NF1. The NIH Flanker may offer the most room for change and offers face validity, which may be beneficial for clinical trials research. However, the LSWM shows most support for relations with behavioral indicators of attention and executive challenges.
本研究调查了 1 型神经纤维瘤病儿童在计算机注意力和执行功能评估中的表现，并探讨了其与 ADHD 症状的关系。参与者包括 37 名 NF1 儿童（20 名男性）（9-13 岁；M=11.02）。参与者完成了 NIH 工具包维度变化卡片分类、列表排序工作记忆（LSWM）和侧抑制任务，以及 Cogstate 识别和 One Back 测试。使用 K-SADS 评估 ADHD 症状。除 LSWM 外，每个指标的平均表现均明显不同于正常均值。NIH 工具包侧抑制和 Cogstate 识别任务检测到至少有轻度困难的参与者比例最高，而 Cogstate 识别任务检测到有严重困难的参与者比例最高。分析显示，两项 NIH 工具包任务与 ADHD 症状存在显著关系。在对 NF1 学龄儿童进行研究时，各种注意力和执行功能的计算机测量方法提供了不同的信息。NIH 侧抑制可能提供最大的变化空间，具有表面效度，这可能对临床试验研究有益。然而，LSWM 对注意力和执行挑战的行为指标的关系提供了最有力的支持。
