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冠状动脉多发弥漫性痉挛:1 例报告。

Sudden diffuse spasm of multiple coronary arteries: A case report.

机构信息

Department of Cardiology, Hebei General Hospital, Hebei North University, Shijiazhuang, Hebei Province, China.

Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.

出版信息

Medicine (Baltimore). 2024 Jan 12;103(2):e36889. doi: 10.1097/MD.0000000000036889.

Abstract

RATIONALE

Diffuse multivessel coronary artery spasm (DMV-CAS) was defined as a severe and reversible diffuse spasm occurring in more than 2 major coronary arteries, which is rare in clinical practice. Due to a wide lesion scope, DMV-CAS often occurs in the form of complications. It is not easy to be clinically diagnosed because it is too brief to be caught. Here, we report a rare case of spontaneous subtotal occlusion of 3 major coronary arteries induced by Vasalva action, which was confirmed in real-time by CAG.

PATIENT CONCERNS

A 68-year-old man had sudden chest pain after forced defecation during hospitalization. The electrocardiogram showed transient ST segment elevation of the inferior wall lead, inversion of the anterior wall, and lateral wall leads T waves. Emergency CAG revealed elongated vessel beds in 3 coronary arteries and multiple diffuse stenosis, but none of the coronary arteries were completely occlusive.

DIAGNOSES

Diagnoses of DMV-CAS were made based on CAG findings and postmedication response.

INTERVENTIONS

Nitroglycerin was administered in the coronary arteries. The anti-vasospasm, antiplatelet aggregation and lipid-regulating drugs were administered orally.

OUTCOMES

The patient was discharged on the 7th day with complete resolution of symptoms and normalization of the electrocardiography findings. No ischemic events occurred during a follow-up for 5 months.

LESSONS

This case highlights the identification of multivessel diffuse coronary spasm and acute myocardial infarction, and the prevention of CAS triggers, which requires the attention of clinicians.

摘要

发病机制

弥漫性多支冠状动脉痉挛(DMV-CAS)定义为在 2 支以上主要冠状动脉中发生的严重且可逆的弥漫性痉挛,在临床实践中较为罕见。由于病变范围广泛,DMV-CAS 常以并发症的形式出现。由于发作时间短暂,难以捕捉,临床上不易诊断。此处我们报告了一例由 Vasalva 动作引起的 3 支主要冠状动脉自发性次全闭塞的罕见病例,该病例通过 CAG 实时得到证实。

病例特点

一名 68 岁男性在住院期间用力排便后突发胸痛。心电图显示下壁导联一过性 ST 段抬高,前壁和侧壁导联 T 波倒置。急诊 CAG 显示 3 支冠状动脉的血管床延长,多处弥漫性狭窄,但无任何一支冠状动脉完全闭塞。

诊断

根据 CAG 结果和药物治疗后的反应,诊断为 DMV-CAS。

干预措施

冠状动脉内给予硝酸甘油。给予抗血管痉挛、抗血小板聚集和调脂药物口服。

治疗结果

患者于第 7 天出院,症状完全缓解,心电图恢复正常。随访 5 个月期间无缺血事件发生。

结论

本病例强调了对多支弥漫性冠状动脉痉挛和急性心肌梗死的识别,以及对 CAS 触发因素的预防,这需要临床医生的关注。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c9/10783403/37a9ff926920/medi-103-e36889-g001.jpg

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