Wang Peng, Cai Feiyu, Li Yu, Yang Xuekang, Feng Rongqin, Lu He, Bai Xiaozhi, Han Juntao
Department of Burns and Cutaneous Surgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Department of Burns and Plastic Surgery & Wound Repair Surgery, the Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Int J Biol Macromol. 2024 Mar;261(Pt 1):129300. doi: 10.1016/j.ijbiomac.2024.129300. Epub 2024 Jan 11.
Currently, there is a rising global incidence of diverse acute and chronic wounds, underscoring the immediate necessity for research and treatment advancements in wound repair. Hydrogels have emerged as promising materials for wound healing due to their unique physical and chemical properties. This review explores the classification and characteristics of hydrogel dressings, innovative preparation strategies, and advancements in delivering and releasing bioactive substances. Furthermore, it delves into the functional applications of hydrogels in wound healing, encompassing areas such as infection prevention, rapid hemostasis and adhesion adaptation, inflammation control and immune regulation, granulation tissue formation, re-epithelialization, and scar prevention and treatment. The mechanisms of action of various functional hydrogels are also discussed. Finally, this article also addresses the current limitations of hydrogels and provides insights into their potential future applications and upcoming innovative designs.
目前，全球各种急慢性伤口的发病率呈上升趋势，这凸显了在伤口修复方面进行研究和治疗进展的迫切必要性。水凝胶因其独特的物理和化学性质，已成为用于伤口愈合的有前景的材料。本文综述了水凝胶敷料的分类和特性、创新的制备策略以及生物活性物质递送和释放方面的进展。此外，还深入探讨了水凝胶在伤口愈合中的功能应用，包括预防感染、快速止血和黏附适应、炎症控制和免疫调节、肉芽组织形成、再上皮化以及瘢痕预防和治疗等领域。还讨论了各种功能性水凝胶的作用机制。最后，本文还阐述了水凝胶目前的局限性，并对其潜在的未来应用和即将出现的创新设计提供了见解。
