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经皮穿刺引流、最大药物治疗联合特利加压素治疗肝性心包积液。

Management of hepatic hydropericardium with open drainage, maximal medical therapy and terlipressin.

机构信息

Gastroenterology and Hepatology, Austin Health, Heidelberg, Victoria, Australia

Gastroenterology and Hepatology, Austin Health, Heidelberg, Victoria, Australia.

出版信息

BMJ Case Rep. 2024 Jan 12;17(1):e256908. doi: 10.1136/bcr-2023-256908.

DOI:10.1136/bcr-2023-256908
PMID:38216161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10806981/
Abstract

We present the case of a woman in her 60s with Child-Pugh C cirrhosis who developed pericardial tamponade during an admission for a haemothorax secondary to a mechanical fall. The patient developed haemodynamic compromise with a rapid decline in renal function. During an open subxiphoid drain tube insertion, a pre-existing peritoneopericardial communication was noted, with ascites in the peritoneal cavity on view. The serum ascites albumin gradient was 14 g/L. Maximal medical therapy was commenced including diuresis and albumin, with adjunctive terlipressin infusion which restored her baseline renal function and resolved the effusion. We believe this is the first case report of using open drainage, maximal medical therapy and terlipressin to successfully treat hepatic hydropericardium and its subsequent renal compromise.

摘要

我们报告了一例 60 多岁的女性患者,患有 Child-Pugh C 级肝硬化,因机械性跌倒导致血胸入院时发生心包填塞。患者出现血流动力学不稳定,肾功能迅速下降。在进行开胸引流管插入时,发现存在先前存在的心包-腹膜交通,腹腔内可见腹水。血清腹水白蛋白梯度为 14g/L。开始进行最大程度的药物治疗,包括利尿剂和白蛋白,并辅助给予特利加压素输注,这恢复了她的基础肾功能并解决了积液问题。我们相信这是首例使用开放引流、最大程度的药物治疗和特利加压素成功治疗肝性心包积液及其随后的肾功能损害的病例报告。

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1
Management of hepatic hydropericardium with open drainage, maximal medical therapy and terlipressin.经皮穿刺引流、最大药物治疗联合特利加压素治疗肝性心包积液。
BMJ Case Rep. 2024 Jan 12;17(1):e256908. doi: 10.1136/bcr-2023-256908.
2
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Eur J Intern Med. 2011 Dec;22(6):587-90. doi: 10.1016/j.ejim.2011.06.013. Epub 2011 Aug 2.
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[Observation of the therapeutic and characteristic effects of terlipressin on refractory cirrhotic ascites].特利加压素治疗顽固性肝硬化腹水的疗效及特点观察
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Hepatic hydropericardium.肝性心包积水
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本文引用的文献

1
Terlipressin-induced skin necrosis.特利加压素引起的皮肤坏死。
BMJ Case Rep. 2021 Nov 29;14(11):e246678. doi: 10.1136/bcr-2021-246678.
2
Management of Ascites in Patients with Cirrhosis: An Update.肝硬化患者腹水的管理:最新进展
J Clin Med. 2021 Nov 10;10(22):5226. doi: 10.3390/jcm10225226.
3
Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction.失代偿期肝硬化的病理生理学:门静脉高压、循环功能障碍、炎症、代谢和线粒体功能障碍。
J Hepatol. 2021 Jul;75 Suppl 1(Suppl 1):S49-S66. doi: 10.1016/j.jhep.2021.01.002.
4
Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome.特利加压素联合白蛋白治疗 1 型肝肾综合征。
N Engl J Med. 2021 Mar 4;384(9):818-828. doi: 10.1056/NEJMoa2008290.
5
Ischemic skin necrosis secondary to the use of terlipressin.继发于特利加压素使用的缺血性皮肤坏死。
Rev Esp Enferm Dig. 2021 Aug;113(8):617. doi: 10.17235/reed.2020.7467/2020.
6
Cirrhotic portal hypertension: From pathophysiology to novel therapeutics.肝硬化门静脉高压症:从病理生理学到新疗法。
World J Gastroenterol. 2020 Oct 28;26(40):6111-6140. doi: 10.3748/wjg.v26.i40.6111.
7
Terlipressin-induced ischaemic skin necrosis.特利加压素诱导的缺血性皮肤坏死。
BMJ Case Rep. 2020 Jan 15;13(1):e233089. doi: 10.1136/bcr-2019-233089.
8
Terlipressin-related Ischaemic Necrosis of the Skin: A Rare Complication.特利加压素相关的皮肤缺血性坏死:一种罕见的并发症。
Eur J Case Rep Intern Med. 2019 Oct 18;6(11):001247. doi: 10.12890/2019_001247. eCollection 2019.
9
Terlipressin versus placebo or no intervention for people with cirrhosis and hepatorenal syndrome.特利加压素与安慰剂或不干预措施治疗肝硬化和肝肾综合征患者的比较
Cochrane Database Syst Rev. 2017 Jun 14;6(6):CD005162. doi: 10.1002/14651858.CD005162.pub4.
10
Terlipressin in the treatment of hepatorenal syndrome: A systematic review and meta-analysis.特利加压素治疗肝肾综合征:一项系统评价与荟萃分析。
Medicine (Baltimore). 2018 Apr;97(16):e0431. doi: 10.1097/MD.0000000000010431.