调控变异网络导致遗传率缺失。

Trans-regulatory variant network contributes to missing heritability.

机构信息

Department of Biology, Concordia University, Montreal, Canada; Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada.

Department of Biology, Concordia University, Montreal, Canada; Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada; Department of Human Genetics, Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Canada.

出版信息

Cell Genom. 2024 Jan 10;4(1):100470. doi: 10.1016/j.xgen.2023.100470.

DOI:10.1016/j.xgen.2023.100470

PMID:38216282

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10794830/

Abstract

In a recent Cell Genomics article, Tsouris et al. analyze the transcriptomes of a large diallel panel of hybrids from Saccharomyces cerevisiae natural isolates to study cis- and trans-regulatory changes underlying gene expression variation. Vanessa Pereira and Elena Kuzmin discuss the authors' findings and the wider context in missing heritability research in this preview.

摘要

在最近的一篇《细胞基因组学》文章中，Tsouris 等人分析了来自酿酒酵母天然分离株的大型双列杂交群体的转录组，以研究基因表达变异背后的顺式和反式调控变化。Vanessa Pereira 和 Elena Kuzmin 在这篇预览中讨论了作者的发现以及在遗传缺失研究中的更广泛背景。