全球基因网络与基因型-表型关系。
Global Genetic Networks and the Genotype-to-Phenotype Relationship.
机构信息
The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada.
Goodman Cancer Research Centre, McGill University, Montreal QC, Canada.
出版信息
Cell. 2019 Mar 21;177(1):85-100. doi: 10.1016/j.cell.2019.01.033.
Abstract
Genetic interactions identify combinations of genetic variants that impinge on phenotype. With whole-genome sequence information available for thousands of individuals within a species, a major outstanding issue concerns the interpretation of allelic combinations of genes underlying inherited traits. In this Review, we discuss how large-scale analyses in model systems have illuminated the general principles and phenotypic impact of genetic interactions. We focus on studies in budding yeast, including the mapping of a global genetic network. We emphasize how information gained from work in yeast translates to other systems, and how a global genetic network not only annotates gene function but also provides new insights into the genotype-to-phenotype relationship.
摘要
遗传相互作用确定了影响表型的遗传变异组合。由于在一个物种的数千个人中都可以获得全基因组序列信息，因此一个主要的悬而未决的问题涉及到遗传性状背后的基因等位基因组合的解释。在这篇综述中，我们讨论了在模式系统中的大规模分析如何阐明遗传相互作用的一般原则和表型影响。我们重点介绍了芽殖酵母中的研究，包括全球遗传网络的映射。我们强调了从酵母研究中获得的信息如何转化到其他系统，以及全球遗传网络不仅注释了基因功能，还为基因型到表型的关系提供了新的见解。
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