Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Centre de Recherche en Biomédicine de Strasbourg (CRBS), L'Institut National de La Santé Et de La Recherche Médicale (Inserm) U1114, University of Strasbourg, Strasbourg, France.
J Neural Transm (Vienna). 2024 May;131(5):475-485. doi: 10.1007/s00702-023-02732-4. Epub 2024 Jan 12.
There is an emerging view that the increased availability of energy-dense foods in our society is contributing to excessive food consumption which could lead to food addiction-like behavior. Particularly, compulsive eating patterns are predominant in people suffering from eating disorders (binge-eating disorder, bulimia and anorexia nervosa) and obesity. Phenotypically, the behavioral pattern exhibits a close resemblance to individuals suffering from other forms of addiction (drug, sex, gambling). Growing body of evidence in neuroscience research is showing that excessive consumption of energy-dense foods alters the brain circuits implicated in reward, decision-making, control, habit formation, and emotions that are central to drug addiction. Here, we review the current understanding of the circuits of food addiction-like behaviors and highlight the future possibility of exploring those circuits to combat obesity and eating disorders.
有一种新观点认为，我们社会中高热量食物的供应增加，导致了过度的食物消费，这可能导致类似于食物成瘾的行为。特别是，强迫性的进食模式在患有饮食障碍（暴食症、贪食症和神经性厌食症）和肥胖的人群中较为普遍。从表型上看，这种行为模式与其他形式成瘾（药物、性、赌博）的个体非常相似。神经科学研究中的大量证据表明，过度摄入高热量食物会改变与奖励、决策、控制、习惯形成和情绪有关的大脑回路，这些回路是药物成瘾的核心。在这里，我们回顾了对类似食物成瘾行为的回路的现有理解，并强调了探索这些回路以对抗肥胖和饮食障碍的未来可能性。
