Pathology Department of The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523713, China.
School of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.
Mol Cell Biochem. 2024 Nov;479(11):2895-2906. doi: 10.1007/s11010-023-04904-y. Epub 2024 Jan 13.
The metabolism of long-chain polyunsaturated fatty acids (LCPUFAs) is closely associated with the risk and progression of colorectal cancer (CRC). This paper aims to investigate the role of LCPUFA in the crosstalk between intestinal microflora and macrophages, as well as the effects of these three parties on the progression of CRC. The metabolism and function of LCPUFA play important roles in regulating the composition of the human gut microflora and participating in the regulation of inflammation, ultimately affecting macrophage function and polarization, which is crucial in the tumor microenvironment. The effects of LCPUFA on cellular interactions between the two species can ultimately influence the progression of CRC. In this review, we explore the molecular mechanisms and clinical applications of LCPUFA in the interactions between intestinal microflora and intestinal macrophages, as well as its significance for CRC progression. Furthermore, we reveal the role of LCPUFA in the construction of the CRC microenvironment and explore the key nodes of the interactions between intestinal flora and intestinal macrophages in the environment. It provides potential targets for the metabolic diagnosis and treatment of CRC.
长链多不饱和脂肪酸（LCPUFAs）的代谢与结直肠癌（CRC）的风险和进展密切相关。本文旨在研究 LCPUFA 在肠道微生物群和巨噬细胞之间相互作用中的作用，以及这三方对 CRC 进展的影响。LCPUFA 的代谢和功能在调节人体肠道微生物群组成和参与炎症调节方面发挥着重要作用，最终影响巨噬细胞的功能和极化，这在肿瘤微环境中至关重要。LCPUFA 对两种细胞之间的细胞相互作用的影响最终可能会影响 CRC 的进展。在这篇综述中，我们探讨了 LCPUFA 在肠道微生物群和肠道巨噬细胞相互作用中的分子机制和临床应用，以及其对 CRC 进展的意义。此外，我们揭示了 LCPUFA 在 CRC 微环境构建中的作用，并探讨了肠道菌群和肠道巨噬细胞在环境中的相互作用的关键节点。为 CRC 的代谢诊断和治疗提供了潜在的靶点。
