Li Juan, Ma Li-Jun, Ma Xiao-Yuan, Gao Bo
Department of Neurology, Xingyuan Hospital of Yulin/4 Hospital of Yulin, Yulin 719000, Shaanxi Province, China.
Department of Clinical Laboratory, The Affiliated Hospital of Yan'an University, Yan'an 716000, Shaanxi Province, China.
World J Psychiatry. 2025 Mar 19;15(3):100909. doi: 10.5498/wjp.v15.i3.100909.
The weight-to-waist index (WWI) serves as an innovative metric specifically designed to assess central obesity. However, the relationship between WWI and the prevalence of post-stroke depression (PSD) remains inadequately explored in the literature.
To elucidate the relationship between WWI and PSD.
Data from the National Health and Nutrition Examination Survey 2005 to 2018 were analyzed. Multivariable logistic regression models and propensity score matching were utilized to investigate the association between WWI and PSD, with adjustments for potential confounders. The restricted cubic spline statistical method was applied to explore non-linear associations.
Participants with elevated WWI values had a significantly greater risk of developing PSD. Specifically, individuals in the higher WWI range exhibited more than twice the likelihood of developing PSD compared to those with lower WWI values (odds ratio = 2.21, 95% confidence interval: 1.84-2.66, < 0.0001). After propensity score matching, the risk of PSD remained significantly elevated (odds ratio = 1.43, 95%confidence interval: 1.09-1.88, = 0.01). Tertile analysis revealed that participants in the highest WWI tertile faced a significantly higher risk of PSD compared to those in the lowest tertile. Restricted cubic spline analysis further revealed a non-linear association, with the risk of PSD plateauing at higher WWI values.
There is a significant association between elevated WWI and increased risk of PSD. Thus, regular depression screening should be implemented in stroke patients with elevated WWI to enhance patient outcomes.
体重与腰围指数（WWI）是一种专门用于评估中心性肥胖的创新指标。然而，WWI与中风后抑郁（PSD）患病率之间的关系在文献中仍未得到充分探讨。
阐明WWI与PSD之间的关系。
分析了2005年至2018年美国国家健康与营养检查调查的数据。采用多变量逻辑回归模型和倾向得分匹配法来研究WWI与PSD之间的关联，并对潜在混杂因素进行了调整。应用受限立方样条统计方法探索非线性关联。
WWI值升高的参与者发生PSD的风险显著更高。具体而言，与WWI值较低的个体相比，WWI范围较高的个体发生PSD的可能性是其两倍多（优势比=2.21，95%置信区间：1.84-2.66，P<0.0001）。倾向得分匹配后，PSD的风险仍然显著升高（优势比=1.43，95%置信区间：1.09-1.88，P=0.01）。三分位数分析显示，WWI最高三分位数的参与者与最低三分位数的参与者相比，PSD风险显著更高。受限立方样条分析进一步揭示了一种非线性关联，PSD风险在较高的WWI值时趋于平稳。
WWI升高与PSD风险增加之间存在显著关联。因此，应在WWI升高的中风患者中定期进行抑郁筛查，以改善患者预后。
