体重调整腰围指数与中老年人群抑郁症状之间的关联：两项前瞻性纵向队列研究的证据

Association Between Weight-Adjusted Waist Index and Depressive Symptoms Among Middle-Aged and Older Adults: Evidence From Two Prospective Longitudinal Cohort Studies.

作者信息

Chen Xingjun, Xu Jianming, Wen Li, Deng Haiyan, Lu Xiaoxi, Liu Guangyan

机构信息

Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.

出版信息

CNS Neurosci Ther. 2025 Jul;31(7):e70496. doi: 10.1111/cns.70496.

DOI:10.1111/cns.70496

PMID:40589318

Abstract

AIM

The association between obesity and depression has been debated. This study aimed to explore the long-term relationship between the weight-adjusted waist index (WWI) and depression in different ethnic groups.

METHODS

This prospective cohort study analyzed data from English Longitudinal Study on Aging (ELSA) and Health and Retirement Study (HRS). The exposure variable was the WWI at baseline, calculated by dividing the waist circumference (cm) by the square root of weight (kg). Depressive symptoms were assessed using the CESD-8. The longitudinal relationship between WWI and depression was analyzed using Cox proportional hazards and restricted cubic spline (RCS) regression models.

RESULTS

During the 12-year follow-up period, depressive symptoms were observed in 55.1% of HRS patients (1851/3359) and 54.8% of ELSA patients (1810/3303). In fully adjusted Cox regression analysis, participants in the 4th quartile of the WWI exhibited a 33% elevated risk of depression (HR = 1.33, 95% CI: 1.15-1.54). Furthermore, the fully adjusted RCS regression model revealed a positive linear association between WWI and the risk of depression.

CONCLUSION

Our studies demonstrated a positive linear correlation between WWI and elevated risk of depression. Alterations in WWI have the potential to predict the occurrence of depression in middle-aged and elderly individuals.

摘要

目的

肥胖与抑郁症之间的关联一直存在争议。本研究旨在探讨不同种族群体中体重调整腰围指数（WWI）与抑郁症之间的长期关系。

方法

这项前瞻性队列研究分析了英国老龄化纵向研究（ELSA）和健康与退休研究（HRS）的数据。暴露变量为基线时的WWI，通过腰围（厘米）除以体重（千克）的平方根计算得出。使用CESD-8评估抑郁症状。采用Cox比例风险模型和受限立方样条（RCS）回归模型分析WWI与抑郁症之间的纵向关系。

结果

在12年的随访期内，HRS患者中有55.1%（1851/3359）出现抑郁症状，ELSA患者中有54.8%（1810/3303）出现抑郁症状。在完全调整的Cox回归分析中，WWI处于第4四分位数的参与者患抑郁症的风险升高了33%（HR = 1.33，95%CI：1.15 - 1.54）。此外，完全调整的RCS回归模型显示WWI与抑郁症风险之间存在正线性关联。