Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil.
Graduate Program in Biological Sciences - Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Clin Nutr ESPEN. 2024 Feb;59:343-354. doi: 10.1016/j.clnesp.2023.12.147. Epub 2023 Dec 27.
Vitamin E is a lipid-soluble nutrient found mainly in vegetable oils and oilseeds. It is divided into eight homologous compounds; however, only α-tocopherol exhibits vitamin activity. Many advantages are related to these compounds, including cellular protection through antioxidant and anti-inflammatory activity, and improving lipid metabolism. Physiopathology of many diseases incepts with reduced antioxidant defense, characterized by an increased reactive oxygen species production and activation of transcription factors involved in inflammation, such as nuclear factor-kappa B (NF-κB), that can be linked to oxidative stress. Moreover, disorders of lipid metabolism can increase the risk of cardiovascular diseases. In addition, intestinal dysbiosis plays a vital role in developing chronic non-communicable diseases. In this regard, vitamin E can be considered to mitigate those disorders, but data still needs to be more conclusive. This narrative review aims to elucidate the mechanisms of action of vitamin E and if supplementation can be beneficial in a disease scenario regarding non-communicable diseases.
维生素 E 是一种脂溶性营养素，主要存在于植物油和油籽中。它分为八种同源化合物，但只有 α-生育酚具有维生素活性。这些化合物具有许多优点，包括通过抗氧化和抗炎活性保护细胞，以及改善脂质代谢。许多疾病的病理生理学始于抗氧化防御的降低，其特征是活性氧的产生增加和参与炎症的转录因子（如核因子-κB (NF-κB)）的激活，这可能与氧化应激有关。此外，脂质代谢紊乱会增加心血管疾病的风险。此外，肠道菌群失调在慢性非传染性疾病的发展中起着至关重要的作用。在这方面，维生素 E 可以被认为是减轻这些疾病的一种方法，但仍需要更多的结论性数据。本综述旨在阐明维生素 E 的作用机制，以及补充维生素 E 是否对非传染性疾病的疾病状态有益。
