Mediterranea Cardiocentro, Napoli, Italy; Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Free Radic Biol Med. 2022 Jan;178:26-41. doi: 10.1016/j.freeradbiomed.2021.11.027. Epub 2021 Nov 25.
Cardiovascular disease (CVD) is one of the major causes of morbidity and mortality and atherosclerosis is the common root to most of the CVD. Oxidative stress is one of the most important factors driving atherosclerosis and its complications. Thus, strategies for the prevention and treatment of cardiovascular events had oxidative changes as a potential target. Natural vitamin E consists of a family of eight different compounds, four tocopherols and four tocotrienols. All tocopherols and tocotrienols are potent antioxidants with lipoperoxyl radical-scavenging activities. In addition, α-tocopherol possesses also anti-inflammatory as well as anti-atherothrombotic effects by modulating platelet and clotting system. Experimental and in vitro studies described molecular and cellular signalling pathways regulated by vitamin E antithrombotic and antioxidant properties. While observational studies demonstrated an inverse association between vitamin E serum levels and CVD, interventional trials with vitamin supplements provided negative results. This review focus on the impact of vitamin E in the atherothrombotic process and describes the results of experimental and clinical studies with the caveats related to the interventional trials with vitamin E to prevent CVD.
心血管疾病 (CVD) 是发病率和死亡率的主要原因之一，动脉粥样硬化是大多数 CVD 的共同根源。氧化应激是驱动动脉粥样硬化及其并发症的最重要因素之一。因此，预防和治疗心血管事件的策略将氧化变化作为一个潜在的目标。天然维生素 E 由八种不同的化合物组成，四种生育酚和四种生育三烯酚。所有的生育酚和生育三烯酚都是具有脂氢过氧基自由基清除活性的强效抗氧化剂。此外，α-生育酚通过调节血小板和凝血系统还具有抗炎和抗动脉粥样血栓形成的作用。实验和体外研究描述了维生素 E 抗血栓形成和抗氧化特性调节的分子和细胞信号通路。虽然观察性研究表明维生素 E 血清水平与 CVD 呈负相关，但维生素补充剂的干预试验结果为阴性。本综述重点关注维生素 E 在动脉粥样血栓形成过程中的作用，并描述了实验和临床研究的结果，并对维生素 E 预防 CVD 的干预试验提出了相关注意事项。
