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帕金森病是后天获得的吗?来自与多发性硬化症的地理比较的证据。

Is Parkinson's disease acquired? Evidence from a geographic comparison with multiple sclerosis.

作者信息

Lux W E, Kurtzke J F

出版信息

Neurology. 1987 Mar;37(3):467-71. doi: 10.1212/wnl.37.3.467.

Abstract

In the coterminous United States, MS mortality rates demonstrate a north-south gradient, which is confirmed by more sophisticated--and more expensive--prevalence studies. Mortality rates from idiopathic Parkinson's disease show a similar north-south gradient, and they correlate significantly with the MS mortality and prevalence data. This demonstration that Parkinson's disease may be place-related provides support for the hypothesis that Parkinson's disease, like MS, is an acquired, environmental illness.

摘要

在美国本土,多发性硬化症的死亡率呈现出南北梯度差异,这一差异在更为复杂(且成本更高)的患病率研究中得到了证实。特发性帕金森病的死亡率也呈现出类似的南北梯度差异,并且与多发性硬化症的死亡率及患病率数据显著相关。帕金森病可能与地域有关这一发现,为帕金森病与多发性硬化症一样是一种后天获得性环境疾病的假说提供了支持。

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