de Rijk M C, Tzourio C, Breteler M M, Dartigues J F, Amaducci L, Lopez-Pousa S, Manubens-Bertran J M, Alpérovitch A, Rocca W A
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
J Neurol Neurosurg Psychiatry. 1997 Jan;62(1):10-5. doi: 10.1136/jnnp.62.1.10.
To assess and compare the prevalence of parkinsonism and Parkinson's disease in five European populations that were surveyed with similar methodology and diagnostic criteria.
Joint analysis of five community surveys--Gironde (France), eight centres in Italy, Rotterdam (The Netherlands), Girona (Spain), and Pamplona (Spain)--in which subjects were screened in person for parkinsonism. Overall, these surveys comprised 14,636 participants aged 65 years or older.
The overall prevalence (per 100 population), age adjusted to the 1991 European standard population, was 2.3 for parkinsonism and 1.6 for Parkinson's disease. The overall prevalence of parkinsonism for the age groups 65 to 69, 70 to 74, 75 to 79, 80 to 84, and 85 to 89 years was respectively, 0.9, 1.5, 3.7, 5.0, and 5.1. The corresponding age specific figures for Parkinson's disease were 0.6, 1.0, 2.7, 3.6, and 3.5. After adjusting for age and sex, the prevalence figures did not differ significantly across studies, except for the French study in which prevalence was lower. Prevalence was similar in men and women. Overall, 24% of the subjects with Parkinson's disease were newly detected through the surveys.
Prevalence of both parkinsonism and Parkinson's disease increased with age, without significant differences between men and women. There was no convincing evidence for differences in prevalence across European countries. A substantial proportion of patients with Parkinson's disease went undetected in the general population.
采用相似的方法和诊断标准，对欧洲五个群体中帕金森综合征和帕金森病的患病率进行评估和比较。
对五项社区调查进行联合分析，这五项调查分别来自法国吉伦特省、意大利的八个中心、荷兰鹿特丹、西班牙赫罗纳和西班牙潘普洛纳，对这些调查中的对象进行帕金森综合征的当面筛查。总体而言，这些调查共有14636名65岁及以上的参与者。
根据1991年欧洲标准人口进行年龄调整后，帕金森综合征的总体患病率（每100人）为2.3，帕金森病为1.6。65至69岁、70至74岁、75至79岁、80至84岁和85至89岁年龄组的帕金森综合征总体患病率分别为0.9、1.5、3.7、5.0和5.1。帕金森病相应的年龄别患病率分别为0.6、1.0,、2.7、3.6和3.5。在对年龄和性别进行调整后，除法国研究中患病率较低外，各研究间的患病率数据无显著差异。男性和女性的患病率相似。总体而言，24%的帕金森病患者是通过这些调查新发现的。
帕金森综合征和帕金森病的患病率均随年龄增长而增加，男性和女性之间无显著差异。没有令人信服的证据表明欧洲国家之间患病率存在差异。在普通人群中，相当一部分帕金森病患者未被发现。
