Division of Haematology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Adv Exp Med Biol. 2023;1442:45-64. doi: 10.1007/978-981-99-7471-9_4.
Hematopoietic stem cells (HSCs) are multipotent stem cells that can self-renew and generate all blood cells of different lineages. The system is under tight control in order to maintain a precise equilibrium of the HSC pool and the effective production of mature blood cells to support various biological activities. Cell metabolism can regulate different molecular activities, such as epigenetic modification and cell cycle regulation, and subsequently affects the function and maintenance of HSC. Upon malignant transformation, oncogenic drivers in malignant hematopoietic cells can remodel the metabolic pathways for supporting the oncogenic growth. The dysregulation of metabolism results in oncogene addiction, implying the development of malignancy-specific metabolism-targeted therapy. In this chapter, we will discuss the significance of different metabolic pathways in hematopoiesis, specifically, the distinctive metabolic dependency in hematopoietic malignancies and potential metabolic therapy.
造血干细胞（HSCs）是多能干细胞，能够自我更新并产生不同谱系的所有血细胞。为了维持 HSC 池的精确平衡和有效产生成熟血细胞以支持各种生物活性，该系统受到严格控制。细胞代谢可以调节不同的分子活动，如表观遗传修饰和细胞周期调节，进而影响 HSC 的功能和维持。在恶性转化时，恶性造血细胞中的致癌驱动因素可以重塑支持致癌生长的代谢途径。代谢的失调导致致癌基因成瘾，这意味着开发针对恶性肿瘤特异性代谢的治疗方法成为可能。在本章中，我们将讨论不同代谢途径在造血中的意义，特别是造血恶性肿瘤中独特的代谢依赖性和潜在的代谢治疗。
