Chen Xiaomei, Li Jie, Liu Jia, Liu Xiao, Deng Menghui, Dong Xunhu, Yang Yanni
School of Nursing, Army Medical University, Chongqing, China.
Department of Medicine, Qionglai Medical Center Hospital, Chengdu, China.
Tob Induc Dis. 2024 Jan 16;22. doi: 10.18332/tid/175973. eCollection 2024.
Some elderly people in China prefer sun-cured tobacco to cigarettes, and the composition of sun-cured tobacco and cigarettes is inconsistent. The influence of cigarettes on the cognitive function of COPD patients has been widely reported, but the research on sun-cured tobacco is relatively rare. Our study explored the association of sun-cured tobacco and cigarette use with cognitive decline in COPD patients.
This was a cross-sectional study. A total of 401 COPD patients were included, and 190, 103, and 108 participants were included in non-smoking, cigarette-smoking, and sun-cured tobacco groups, respectively. We evaluated the global cognitive function using the Beijing version of the Montreal Cognitive Assessment, verbal fluency function using an animal fluency test, and memory function using ten unrelated words.
The participants of both cigarette-smoking (AOR=11.18; 95% CI: 1.28- 97.5) and sun-cured tobacco (AOR=10.46; 95% CI: 1.14-96.4) groups were more likely to develop mild cognitive impairment compared to the non-smoking group. The mean z scores of global cognitive function, verbal fluency, and memory were lower in cigarette-smoking and sun-cured tobacco groups than those in a non-smoking group; Multivariable linear regression showed that global cognitive function (β= -0.61; 95% CI: -1.04 - -0.18; and β= -0.48; 95% CI: -0.91 - -0.05) and verbal fluency (β= -0.79; 95% CI: -1.33 - -0.26; and β= -0.69; 95% CI: -1.23 - -0.16) of the sun-cured tobacco group and the cigarette-smoking group were significantly lower than those of the non-smoking group when adjusting for demographic and disease-related characteristics. However, there was no significant difference between the cigarette-smoking and sun-cured tobacco groups in global cognitive function, verbal fluency, and memory.
Compared with non-smokers, the use of cigarettes and sun-cured tobacco may damage the cognitive function of COPD patients, especially in global cognitive function and verbal fluency.
中国一些老年人更喜欢晒烟而非香烟，且晒烟和香烟的成分不一致。香烟对慢性阻塞性肺疾病（COPD）患者认知功能的影响已有广泛报道，但关于晒烟的研究相对较少。我们的研究探讨了晒烟和香烟使用与COPD患者认知功能下降之间的关联。
这是一项横断面研究。共纳入401例COPD患者，其中非吸烟组、吸烟组和晒烟组分别有190例、103例和108例参与者。我们使用北京版蒙特利尔认知评估量表评估整体认知功能，使用动物流畅性测试评估语言流畅性功能，使用十个不相关单词评估记忆功能。
与非吸烟组相比，吸烟组（调整后比值比[AOR]=11.18；95%置信区间[CI]：1.28 - 97.5）和晒烟组（AOR=10.46；95% CI：1.14 - 96.4）的参与者更易发生轻度认知障碍。吸烟组和晒烟组的整体认知功能、语言流畅性和记忆的平均z分数低于非吸烟组；多变量线性回归显示，在调整人口统计学和疾病相关特征后，晒烟组和吸烟组的整体认知功能（β=-0.61；95% CI：-1.04 - -0.18；以及β=-0.48；95% CI：-0.91 - -0.05）和语言流畅性（β=-0.79；95% CI：-1.33 - -0.26；以及β=-0.69；95% CI：-1.23 - -0.16）显著低于非吸烟组。然而，吸烟组和晒烟组在整体认知功能、语言流畅性和记忆方面无显著差异。
与不吸烟者相比，使用香烟和晒烟可能损害COPD患者的认知功能，尤其是在整体认知功能和语言流畅性方面。
