Department of Nephrology, People's Hospital of Zhengzhou University, He'nan Provincial People's Hospital, He'nan Provincial Key Laboratory of Kidney Disease and Immunology, Zhengzhou, China.
Front Endocrinol (Lausanne). 2024 Jan 2;14:1308719. doi: 10.3389/fendo.2023.1308719. eCollection 2023.
This study examined the association between the metabolic score for insulin resistance (METS-IR), a novel surrogate indicator of insulin resistance, and brachial-ankle pulse wave velocity (baPWV) in Japanese health check participants.
A cross-sectional research was conducted involving individuals in a program of medical health screening at the Medical Health Check-up Center in Japan. The study assessed the connection between METS-IR and baPWV in 912 participants who joined the program between 3/1/2004 and 12/31/2012. Serum laboratory tests and lifestyle surveys were the covariates. Multivariate linear regression analysis and subgroup analyses were performed.
912 participants were involved in this cross-sectional study. Adjusted for age, sex, BMI, AST, UA, HDL, eGFR, ankle-brachial index (ABI), alcohol consumption, and smoking status, multivariate linear regression analysis showed that METS-IR and baPWV showed a significant positive association (adjusted β=15.3, 95% confidence interval (CI): 6.6123.98) with METS-IR as a continuous variable. When converting METS-IR to quartile categorical variables, higher quartile METS-IR indices had longer baPWV (Q3 vs Q1, β=86.14, 95% CI: 23.45148.83; Q4 vs Q1, β=125.41, 95% CI: 39.99210.84). In subgroup analysis, METS-IR was associated with baPWV in people with eGFR > 60 ml/min (adjusted β= 14.44, 95% CI: 5.6123.26, P=0.001), none or light alcohol consumption (adjusted β=16.92, 95% CI: 6.8527, P=0.001), non-smokers (adjusted β=15.48, 95% CI: 5.8625.1, P=0.002), non-regular exercisers(adjusted β=17.34, 95% CI: 8.0326.65, P<0.001), non-fatty liver (adjusted β=17.65, 95% CI: 5.9229.39, P=0.003), and non-hypertensive (adjusted β=16.13, 95% CI:8.45~23.8, P<0.001).
METS-IR are remarkably associated with baPWV among health check-up participants in Gifu, Japan. As a simple, easily calculated predictor of arterial stiffness, METS-IR could be considered for primary care as a monitoring tool to identify people with high risk of cardiovascular disease in order to intervene early on risk factors. Future prospective, large-sample researches are still needed to confirm this.
本研究旨在探讨代谢胰岛素抵抗评分（METS-IR）与肱踝脉搏波速度（baPWV）之间的关系，METS-IR 是胰岛素抵抗的一种新的替代指标，在日本健康检查参与者中。
采用横断面研究方法，对参加日本医疗健康检查中心体检计划的个体进行研究。该研究评估了 912 名于 2004 年 3 月 1 日至 2012 年 12 月 31 日期间参加该计划的参与者的 METS-IR 与 baPWV 之间的关系。血清实验室检查和生活方式调查是协变量。进行了多元线性回归分析和亚组分析。
共有 912 名参与者参与了这项横断面研究。调整年龄、性别、BMI、AST、UA、HDL、eGFR、踝臂指数（ABI）、酒精摄入量和吸烟状况后，多元线性回归分析显示 METS-IR 与 baPWV 呈显著正相关（调整β=15.3，95%置信区间（CI）：6.6123.98），METS-IR 为连续变量。当将 METS-IR 转换为四分位categorical 变量时，较高四分位 METS-IR 指数的 baPWV 更长（Q3 与 Q1，β=86.14，95%CI：23.45148.83；Q4 与 Q1，β=125.41，95%CI：39.99210.84）。在亚组分析中，在 eGFR>60ml/min（调整β=14.44，95%CI：5.6123.26，P=0.001）、非或轻度饮酒（调整β=16.92，95%CI：6.8527，P=0.001）、非吸烟者（调整β=15.48，95%CI：5.8625.1，P=0.002）、非定期运动者（调整β=17.34，95%CI：8.0326.65，P<0.001）、非脂肪肝（调整β=17.65，95%CI：5.9229.39，P=0.003）和非高血压（调整β=16.13，95%CI：8.45~23.8，P<0.001）的人群中，METS-IR 与 baPWV 显著相关。
METS-IR 与日本岐阜县健康检查参与者的 baPWV 显著相关。作为动脉僵硬的简单、易于计算的预测指标，METS-IR 可以作为初级保健的监测工具，以识别心血管疾病风险较高的人群，从而早期干预风险因素。仍需要未来的前瞻性、大样本研究来证实这一点。
