OST-01是一种来自菊叶酒神菊的天然产物，靶向急性髓系白血病中c-Myc依赖的核糖体生物合成。 - Suppr

OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia.

作者信息

Kang HyunJun, Hoang Dinh Hoa, Valerio Melissa, Pathak Khyatiben, Zhang Lianjun, Buettner Ralf, Chen Fang, Estrella Katrina, Graff William, Li Zhuo, Xie Jun, Horne David, Kuo Ya-Huei, Zhang Bin, Pirrotte Patrick, Nguyen Le Xuan Truong, Marcucci Guido

机构信息

Department of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA, USA.

Cancer & Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA.

出版信息

Leukemia. 2024 Mar;38(3):657-662. doi: 10.1038/s41375-024-02146-5. Epub 2024 Jan 17.

DOI:10.1038/s41375-024-02146-5

PMID:38233463

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10912030/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c7/10912030/4153a0cacd66/41375_2024_2146_Fig1_HTML.jpg

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OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia.

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