Yang Yunhan, Li Yanping, Sears Rosalie C, Sun Xiao-Xin, Dai Mu-Shui
Department of Molecular & Medical Genetics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Front RNA Res. 2024;2. doi: 10.3389/frnar.2024.1389104. Epub 2024 Apr 3.
Ribosome biogenesis is essential for cell growth, proliferation, and animal development. Its deregulation leads to various human disorders such as ribosomopathies and cancer. Thus, tight regulation of ribosome biogenesis is crucial for normal cell homeostasis. Emerging evidence suggests that posttranslational modifications such as ubiquitination and SUMOylation play a crucial role in regulating ribosome biogenesis. Our recent studies reveal that USP36, a nucleolar deubiquitinating enzyme (DUB), acts also as a SUMO ligase to regulate nucleolar protein group SUMOylation, thereby being essential for ribosome biogenesis. Here, we provide an overview of the current understanding of the SUMOylation regulation of ribosome biogenesis and discuss the role of USP36 in nucleolar SUMOylation.
核糖体生物发生对于细胞生长、增殖和动物发育至关重要。其失调会导致各种人类疾病，如核糖体病和癌症。因此，严格调控核糖体生物发生对于正常细胞稳态至关重要。新出现的证据表明，泛素化和SUMO化等翻译后修饰在调控核糖体生物发生中起关键作用。我们最近的研究表明，核仁去泛素化酶（DUB）USP36也作为一种SUMO连接酶来调节核仁蛋白组的SUMO化，从而对核糖体生物发生至关重要。在这里，我们概述了目前对核糖体生物发生的SUMO化调控的理解，并讨论了USP36在核仁SUMO化中的作用。
