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一种使用3D打印微流控通道对多种分析物进行低成本、快速且同时比色检测的新方法。

A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels.

作者信息

Mishra Piyush, Navariya Sagar, Gupta Priyanshi, Singh Bhupendra Pratap, Chopra Samridhi, Shrivastava Swapnil, Agrawal Ved Varun

机构信息

CSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, India.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

出版信息

R Soc Open Sci. 2024 Jan 17;11(1):231168. doi: 10.1098/rsos.231168. eCollection 2024 Jan.

DOI:10.1098/rsos.231168
PMID:38234445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10791535/
Abstract

This research paper presents an inventive technique to swiftly create microfluidic channels on distinct membrane papers, enabling colorimetric drug detection. Using a modified DIY RepRap 3D printer with a syringe pump, microfluidic channels (µPADs) are crafted on a flexible nylon-based substrate. This allows simultaneous detection of four common drugs with a single reagent. An optimized blend of polydimethylsiloxane (PDMS) dissolved in hexane is used to create hydrophobic channels on various filter papers. The PDMS-hexane mixture infiltrates the paper's pores, forming hydrophobic barriers that confine liquids within the channels. These barriers are cured on the printer's hot plate, controlling channel width and preventing spreading. Capillary action drives fluid along these paths without spreading. This novel approach provides a versatile solution for rapid microfluidic channel creation on membrane papers. The DIY RepRap 3D printer integration offers precise control and faster curing. The PDMS-hexane solution accurately forms hydrophobic barriers, containing liquids within desired channels. The resulting microfluidic system holds potential for portable, cost-effective drug detection and various sensing applications.

摘要

本研究论文提出了一种创新技术，可在不同的膜纸上快速创建微流控通道，实现比色法药物检测。使用带有注射泵的改良型DIY RepRap 3D打印机，在柔性尼龙基基材上制作微流控通道（µPADs）。这使得用单一试剂同时检测四种常见药物成为可能。将溶解在己烷中的聚二甲基硅氧烷（PDMS）进行优化混合，用于在各种滤纸上创建疏水通道。PDMS - 己烷混合物渗入纸张孔隙，形成疏水屏障，将液体限制在通道内。这些屏障在打印机的热板上固化，控制通道宽度并防止扩散。毛细作用驱动流体沿着这些路径流动而不扩散。这种新颖的方法为在膜纸上快速创建微流控通道提供了一种通用解决方案。DIY RepRap 3D打印机的集成提供了精确控制和更快的固化。PDMS - 己烷溶液准确地形成疏水屏障，将液体容纳在所需的通道内。由此产生的微流控系统在便携式、经济高效的药物检测和各种传感应用方面具有潜力。

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