Hu Fangke, Xue Lu, Zhao Dong, Chen Chao, Liu Gang, Yang Qiang
Department of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin 300000, P.R. China.
Exp Ther Med. 2023 Dec 18;27(2):66. doi: 10.3892/etm.2023.12354. eCollection 2024 Feb.
Spinal gout is a relatively rare disease characterized by significant clinical symptoms. In the current study, the first case of spinal gout with tophus in the intervertebral foramen, which perfectly mimicked degenerative lumbar disc disorders, was presented. The patient was a 57-year-old man with a medical history of gout who had suffered from progressive neurological deterioration for the last 12 months. Imaging examination revealed bilateral stenosis in the L5/S1 intervertebral foramen, mimicking degenerative lumbar disc disease. Nerve root radiculography and blocking were performed and the neurological symptoms were completely relieved. Open surgery was further performed and unexpectedly, the intra-operative findings were amorphous chalky white lesions. Histopathology confirmed the diagnosis of spinal gout. After surgery, the patient was prescribed a medication and achieved complete remission of clinical symptoms. No deterioration was found at the 1-year follow-up. To the best of our knowledge, this is the first report of spinal gout tophus in intervertebral foramen in the literature. It was concluded that, although intraspinal tophaceous gout is relatively rare, orthopedic surgeons should take it into consideration as a differential diagnosis, particularly if the patient has a medical history of gout. Early diagnosis and timely medical management may possibly be able to avoid neurological compromise and the need for surgery.
脊柱痛风是一种相对罕见的疾病,具有明显的临床症状。在本研究中,报告了首例椎间孔有痛风石的脊柱痛风病例,该病例酷似退行性腰椎间盘疾病。患者为一名57岁男性,有痛风病史,在过去12个月中出现进行性神经功能恶化。影像学检查显示L5/S1椎间孔双侧狭窄,类似退行性腰椎间盘疾病。进行了神经根造影和阻滞,神经症状完全缓解。进一步进行了开放手术,术中意外发现为无定形的灰白色病变。组织病理学确诊为脊柱痛风。术后给患者开了药,临床症状完全缓解。1年随访未发现病情恶化。据我们所知,这是文献中首例关于椎间孔脊柱痛风石的报告。结论是,尽管脊髓痛风石相对罕见,但骨科医生应将其作为鉴别诊断考虑,特别是如果患者有痛风病史。早期诊断和及时的医疗管理可能能够避免神经功能损害和手术需求。